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Table 3 Comparing p-values for EcoCyc ARGSYN-PWY and KEGG map00220

From: Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

Count of Significantly Expressed Genes

EcoCyc p-value

Corrected for Multiple Comparisons

Native KEGG p-value

Corrected for Multiple Comparisons

12

1.7×10−28

6.0×10−26

1.8×10−26

2.1×10−24

11

1.8×10−25

6.5×10−23

4.2×10−24

5.0×10−22

10

1.0×10−22

3.5×10−20

8.8×10−22

1.0×10−19

9

3.6×10−20

1.3×10−17

1.6×10−19

1.9×10−17

8

9.8×10−18

3.5×10−15

2.7×10−17

3.3×10−15

7

2.1×10−15

7.6×10−13

4.2×10−15

5.0×10−13

6

3.9×10−13

1.4×10−10

5.9×10−13

7.0×10−11

5

6.1×10−11

2.1×10−8

7.6×10−11

9.0×10−9

4

8.3×10−9

2.9×10−6

9.1×10−9

1.1×10−6

3

1.0×10−6

3.6×10−4

1.0×10−6

1.2×10−4

2

1.1×10−4

3.9×10−2

1.1×10−4

1.3×10−2

1

1.1×10−2

1.0

1.1×10−2

1.0

  1. Corrected p-values to the right of each p-value column use Bonferroni as a “worst case” correction as discussed in the text