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Table 4 Comparing p-values for EcoCyc PWY0-901 and KEGG map00450

From: Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

Count of Significantly Expressed Genes EcoCyc p-value Corrected for Multiple Comparisons Native KEGG p-value Corrected for Multiple Comparisons
4 1.7×10−11 5.9×10−9 7.2×10−9 8.5×10−7
3 1.8×10−8 6.5×10−6 8.5×10−7 1.0×10−4
2 1.0×10−5 3.5×10−3 9.6×10−5 1.1×10−2
1 3.6×10−3 1.0 1.0×10−2 1.0
  1. Corrected p-values to the right of each p-value column use Bonferroni as a “worst case” correction as discussed in the text