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Table 6 Comparing p-values for EcoCyc Guanosine deoxyribonucleotides de novo biosynthesis II (PWY-7222) and KEGG map00230

From: Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

Count of Significantly Expressed Genes EcoCyc p-value Corrected for Multiple Comparisons Native KEGG p-value Corrected for Multiple Comparisons
10 1.51×10−24 5.35×10−22 2.53×10−14 3.01×10−12
9 1.64×10−21 5.82×10−19 6.14×10−13 7.31×10−11
8 8.94×10−19 3.16×10−16 1.47×10−11 1.75×10−9
7 3.25×10−16 1.15×10−13 3.48×10−10 4.14×10−8
6 8.84×10−14 3.13×10−11 8.12×10−9 9.67×10−7
5 1.93×10−11 6.83×10−9 1.87×10−7 2.23×10−5
4 3.51×10−9 1.24×10−6 4.25×10−6 5.06×10−4
3 5.48×10−7 1.94×10−4 9.54×10−5 1.14×10−2
2 7.50×10−5 2.65×10−2 2.11×10−3 2.52×10−1
1 9.12×10−3 1.0 4.63×10−2 1.00
  1. Corrected p-values use Bonferroni as a ’worst case’ correction as discussed in the text
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