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Table 6 Comparing p-values for EcoCyc Guanosine deoxyribonucleotides de novo biosynthesis II (PWY-7222) and KEGG map00230

From: Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

Count of Significantly Expressed Genes

EcoCyc p-value

Corrected for Multiple Comparisons

Native KEGG p-value

Corrected for Multiple Comparisons

10

1.51×10−24

5.35×10−22

2.53×10−14

3.01×10−12

9

1.64×10−21

5.82×10−19

6.14×10−13

7.31×10−11

8

8.94×10−19

3.16×10−16

1.47×10−11

1.75×10−9

7

3.25×10−16

1.15×10−13

3.48×10−10

4.14×10−8

6

8.84×10−14

3.13×10−11

8.12×10−9

9.67×10−7

5

1.93×10−11

6.83×10−9

1.87×10−7

2.23×10−5

4

3.51×10−9

1.24×10−6

4.25×10−6

5.06×10−4

3

5.48×10−7

1.94×10−4

9.54×10−5

1.14×10−2

2

7.50×10−5

2.65×10−2

2.11×10−3

2.52×10−1

1

9.12×10−3

1.0

4.63×10−2

1.00

  1. Corrected p-values use Bonferroni as a ’worst case’ correction as discussed in the text