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Table 7 Comparing p-values for EcoCyc pyrimidine deoxyribonucleotides de novo biosynthesis I (PWY-7184) and KEGG map00240

From: Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

Count of Significantly Expressed Genes EcoCyc p-value Corrected for Multiple Comparisons Native KEGG p-value Corrected for Multiple Comparisons
13 2.03×10−30 7.19×10−28 3.49×10−21 4.16×10−19
12 2.20×10−27 7.79×10−25 1.50×10−19 1.78×10−17
11 1.19×10−24 4.23×10−22 6.28×10−18 7.47×10−16
10 4.32×10−22 1.53×10−19 2.57×10−16 3.05×10−14
9 1.18×10−19 4.16×10−17 1.02×10−14 1.22×10−12
8 2.56×10−17 9.05×10−15 4.00×10−13 4.76×10−11
7 4.64×10−15 1.64×10−12 1.53×10−11 1.82×10−9
6 7.23×10−13 2.56×10−10 5.70×10−10 6.78×10−8
5 9.86×10−11 3.49×10−8 2.08×10−8 2.48×10−6
4 1.20×10−8 4.23×10−6 7.45×10−7 8.86×10−5
3 1.31×10−6 4.63×10−4 2.61×10−5 3.11×10−3
2 1.30×10−4 4.60×10−2 8.98×10−4 1.07×10−1
1 1.19×10−2 1.00 3.02×10−2 1.00
  1. Corrected p-values use Bonferroni as a ’worst case’ correction as discussed in the text