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Table 7 Comparing p-values for EcoCyc pyrimidine deoxyribonucleotides de novo biosynthesis I (PWY-7184) and KEGG map00240

From: Pathway size matters: the influence of pathway granularity on over-representation (enrichment analysis) statistics

Count of Significantly Expressed Genes

EcoCyc p-value

Corrected for Multiple Comparisons

Native KEGG p-value

Corrected for Multiple Comparisons

13

2.03×10−30

7.19×10−28

3.49×10−21

4.16×10−19

12

2.20×10−27

7.79×10−25

1.50×10−19

1.78×10−17

11

1.19×10−24

4.23×10−22

6.28×10−18

7.47×10−16

10

4.32×10−22

1.53×10−19

2.57×10−16

3.05×10−14

9

1.18×10−19

4.16×10−17

1.02×10−14

1.22×10−12

8

2.56×10−17

9.05×10−15

4.00×10−13

4.76×10−11

7

4.64×10−15

1.64×10−12

1.53×10−11

1.82×10−9

6

7.23×10−13

2.56×10−10

5.70×10−10

6.78×10−8

5

9.86×10−11

3.49×10−8

2.08×10−8

2.48×10−6

4

1.20×10−8

4.23×10−6

7.45×10−7

8.86×10−5

3

1.31×10−6

4.63×10−4

2.61×10−5

3.11×10−3

2

1.30×10−4

4.60×10−2

8.98×10−4

1.07×10−1

1

1.19×10−2

1.00

3.02×10−2

1.00

  1. Corrected p-values use Bonferroni as a ’worst case’ correction as discussed in the text