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Fig. 2 | BMC Genomics

Fig. 2

From: Differential microRNAs expression profiles in liver from three different lifestyle modification mice models

Fig. 2

Numbers and ratios of detected (a), accepted (a, b) and differentially expressed (c, d) microRNAs. The profiling by microRNA array identified a subset of microRNAs that were differentially expressed. The intensity of green signal on the chip were calculated after background subtraction and replicated spots on the same slide have been averaged by getting a median intensity. Median Normalization Method was used to obtain “Normalized Data”, Normalized Data = (Foreground-Background)/median, the median is 50% quantile of microRNA intensity which is larger than 50 in all samples after background correction. The low intensity differentially expressed microRNAs were filtered (Foreground-Background intensities of which are all < 50 in two compared samples) then we got accepted microRNAs. The threshold value used to screen Up and Down regulated microRNAs is Fold Change> = 1.5 compared to AL group. AL: ad libitum, CR: caloric restriction, EX: exercise, HF: high-fat diet, DE: differentially expressed

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