Table 1 The top 10 enriched GO terms and KEGG pathways

Common in CR, EX and HF

oxidation-reduction process;

lipid metabolic process;

metabolic process;

fatty acid metabolic process;

blood coagulation;

hemostasis;

steroid metabolic process;

lipid homeostasis

intracellular membrane-bounded organelle;

extracellular exosome;

mitochondrion;

endoplasmic reticulum;

blood microparticle;

peroxisome;

membrane;

extracellular region

oxidoreductase activity;

catalytic activity;

monooxygenase activity;

flavin adenine dinucleotide binding;

iron ion binding;

oxidoreductase activity (acting on paired donors, with incorporation or reduction of molecular oxygen)

Metabolic pathways;

PPAR signaling pathway;

Fatty acid degradation;

Complement and coagulation cascades;

Biosynthesis of antibiotics;

Retinol metabolism;

Chemical carcinogenesis

Common in CR and EX

triglyceride metabolic process

–

–

–

Common in CR and HF

–

cytosol

transferase activity;

hydrolase activity

–

Common in EX and HF

–

mitochondrial inner membrane

heme binding

Tryptophan metabolism;

Valine, leucine and isoleucine degradation

Only in CR

fatty acid beta-oxidation

extracellular space

fatty-acyl-CoA binding;

oxidoreductase activity (acting on the CH-CH group of donors)

Ascorbate and aldarate metabolism;

Butanoate metabolism;

Fatty acid metabolism

Only in EX

xenobiotic metabolic process

cytoplasm

lyase activity;

metal ion binding;

pyridoxal phosphate binding

Steroid hormone biosynthesis

Only in HF

cholesterol homeostasis,

steroid biosynthetic process

–

protein homodimerization activity

Peroxisome