Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer’s disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis

Table 1. Significantly-changed pathways in the Goseq analysis of Hallmark, KEGG and Wiki pathways filtered by a FDR cutoff of 0.05

Pathway	DE genes	Genes in category	FDR
Hallmark pathway
G2M_CHECKPOINT	19	182	1.37E-10
E2F_TARGETS	13	174	2.53E-05
KEGG pathway
DNA_REPLICATION	7	34	4.17E-06
CELL_CYCLE	8	109	5.29E-04
Wiki pathway
DNA Replication	6	31	4.26E-05
Cell cycle	7	71	2.08E-04
G1 to S cell cycle control	6	49	2.24E-04

ISSN: 1471-2164