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Fig. 8 | BMC Genomics

Fig. 8

From: Comparative transcriptome analysis reveals ectopic delta-5 and delta-6 desaturases enhance protective gene expression upon Vibrio vulnificus challenge in Tilapia (Oreochromis niloticus)

Fig. 8

Proposed mechanism of Delta 5 and Delta 6 transgenic (D56) mediated ω-3 fatty acid metabolism to enhance resistance against V. vulnificus in Tilapia. a The ω-3 fatty acids synthesized in D56 transgenic fish regulates or activates the extra cellular acting agents such as Antimicrobial peptide (AMP), Complement system and ACKR4 by altering their expression. b In cytosol D56 mediated ω-3 fatty acid regulates HNF4A, TLR-5 and TLR-2, PPARs, TIMP2 and PRDX1. c In nucleus transcription factors such as NF-κB is altered to regulate the proinflammatory cytokines. (Image from ourselves)

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BMC Genomics

ISSN: 1471-2164

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