Table 4 KEGG pathway enrichment analysis of wild-type and transgenic tilapia fish expressing delta-6 desaturase plus delta-5 desaturase (D56) infected with V. vulnificus for 24 h
Pathway ID | Pathway | DEGs with pathway annotation | Corrected P-value |
|---|---|---|---|
onl00010 | Glycolysis / Gluconeogenesis | 17 | 2E-09 |
onl01200 | Carbon metabolism | 17 | 1E-05 |
onl04146 | Peroxisome | 13 | 3E-05 |
onl00071 | Fatty acid degradation | 9 | 4E-05 |
onl01230 | Biosynthesis of amino acids | 12 | 5E-05 |
onl03320 | PPAR signaling pathway | 11 | 0.0002 |
onl00830 | Retinol metabolism | 9 | 0.0006 |
onl00051 | Fructose and mannose metabolism | 7 | 0.0007 |
onl00982 | Drug metabolism - cytochrome P450 | 8 | 0.0019 |
onl00980 | Metabolism of xenobiotics by cytochrome P450 | 8 | 0.0021 |
onl00590 | Arachidonic acid metabolism | 9 | 0.003 |
onl00640 | Propanoate metabolism | 5 | 0.0047 |
onl00100 | Steroid biosynthesis | 4 | 0.005 |
onl00330 | Arginine and proline metabolism | 7 | 0.0052 |
onl00410 | beta-Alanine metabolism | 5 | 0.0066 |
onl00650 | Butanoate metabolism | 4 | 0.0068 |
onl00053 | Ascorbate and aldarate metabolism | 5 | 0.0091 |
onl04060 | Cytokine-cytokine receptor interaction | 18 | 0.0101 |
onl00140 | Steroid hormone biosynthesis | 7 | 0.0108 |
onl00380 | Tryptophan metabolism | 6 | 0.011 |
onl00250 | Alanine, aspartate and glutamate metabolism | 6 | 0.0119 |
onl04920 | Adipocytokine signaling pathway | 8 | 0.012 |
onl00052 | Galactose metabolism | 5 | 0.0121 |
onl00350 | Tyrosine metabolism | 5 | 0.0144 |
onl04350 | TGF-beta signaling pathway | 10 | 0.0155 |
onl00620 | Pyruvate metabolism | 5 | 0.0185 |
onl04110 | Cell cycle | 10 | 0.0226 |
onl00260 | Glycine, serine and threonine metabolism | 5 | 0.0233 |
onl00360 | Phenylalanine metabolism | 3 | 0.0291 |
onl00760 | Nicotinate and nicotinamide metabolism | 5 | 0.0308 |
onl01212 | Fatty acid metabolism | 6 | 0.0369 |
onl02010 | ABC transporters | 5 | 0.0396 |
onl00500 | Starch and sucrose metabolism | 4 | 0.0494 |