Table 4 Biological significance of gene set that aid in prediction of BRCA survival and drug response
GENE | NAME | Reported Biomarker function |
|---|---|---|
EFHD1 | EF-Hand Domain Family Member D1 | Part of digital RNA resistance signature to predict response to breast cancer therapy [31] |
CDH1 | Cadherin 1 | CDH1 structural alterations as novel prognostic biomarker in gastric cancer patients [32] CDH1 gene as a prognostic biomarker in hepatocellular carcinoma [33] |
PIK3CA | Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | PIK3CA is a predictive biomarker for use of alpelisib and fulvestrant in BRCA patients [34] |
TP53 | Â | mutant p53 as a possible therapeutic target and biomarker for breast cancer [35] |