Table 5 Clinically relevant SNPs associated with BDNF expression across brain regions of interest

rs16917204

C = 0.2298

Intron, gene body,

Chromosome 11,

Position: 27646808

• Methamphetamine abuse [15]

• Panic disorders [16]

• Alzheimers Disease [17]

• Schizophrenia [18]

rs6265

T = 0.2013

Exon, gene body,

Chromosome 11,

Position: 27658369

• Major depressive disorder [19]

• Bipolar disorder [20]

• Obsessive-compulsive disorder [21]

• Alzheimer’s disease [22]

rs11030104

G = 0.2226

Intron, gene body,

Chromosome 11,

Position: 27662970

• Increased BMI [23]

• BMI and Smoking [24]

• Alzheimer’s disease [22]

rs7103411

C = 0.2470

Intron, gene body,

Chromosome 11,

Position: 27678578

• Epilepsy [25]

rs16917237

T = 0.2214

Intron, gene body,

Chromosome 11,

Position: 27680836

• Eating disorders, increased BMI [26]

• Bipolar disorder [27]

rs6484320

T = 0.2468

Intron, gene body,

Chromosome 11,

Position: 27681641

• Epilepsy (in Fragile x-syndrome) [28]

• Smoking and nicotine addiction [29]

rs988748

C = 0.2430

Intron, gene body,

Chromosome 11,

Position: 27703198

• Major depressive disorder [19]

• Smoking and nicotine addiction [29]

rs2049045

C = 0.0629

Intron, gene body,

Chromosome 11,

Position: 27672694

• Alzheimer’s disease-related depression [30]

• Bipolar disorder [31]

• Alzheimer’s disease [22]