Fig. 1

Methamphetamine-induced changes in gene expression are more prevalent in female hearts than in male hearts. RNA sequencing identified changes in the transcription of 346 genes. Changes in 340 genes were identified 24 h after the last methamphetamine injection a. Only 6 changes were identified following 30 days of subsequent abstinence b. Most (97%) methamphetamine-induced changes in gene transcription were sex dependent with the majority (82%) occurring exclusively in female hearts a. Methamphetamine induced changes in only 9 transcripts that were common to both male and female hearts a, c