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Table 1 Heart weight and heart weight / body weight ratio of rats following 10 days of saline / methamphetamine injections or 10 days saline / methamphetamine injections followed by 30 days of subsequent abstinence. Data represent the mean ± SEM of 6 animals

From: Methamphetamine-induced changes in myocardial gene transcription are sex-dependent

 

N

Heart weight (g)

Heart weight / body weight ratio (mg/g)

Weight Gain (g)

Group 1: Male 10 days saline

6

1.5 ± 0.05

3.9 ± 0.2

46 ± 1

Group 2: Male 10 days methamphetamine

6

1.6 ± 0.06

4.1 ± 0.1

37 ± 2

Group 3: Female 10 days saline

6

0.95 ± 0.04a

4.5 ± 0.1

19 ± 2a

Group 4: Female 10 days methamphetamine

6

0.95 ± 0.02b

4.5 ± 0.1

11 ± 2b

Group 5: Male 10 days saline + 30 days abstinence

6

1.7 ± 0.06a

3.8 ± 0.1

104 ± 6a

Group 6: Male 10 days methamphetamine + 30 days abstinence

6

1.7 ± 0.06

3.6 ± 0.2

110 ± 8g

Group 7: Female 10 days saline + 30 days abstinence

6

1.2 ± 0.03c

4.0 ± 0.2e

46 ± 2c

Group 8: Female 10 days methamphetamine + 30 days abstinence

6

1.1 ± 0.02d

3.8 ± 0.1f

44 ± 7d

  1. Three-way ANOVA indicated significant effects of sex [F = 353 (1, 40) p < 0.0001] and time (10 days treatment vs 10 days treatment + 30 days abstinence) [F = 42 (1, 40), p < 0.0001] on heart weight. There were also significant effects of sex [F = 12 (1, 40), p = 0.001] and time [F = 24 (1, 40), p < 0.0001] on heart weight / body weight ratio and significant effects of sex [F = 311 (1, 64), p < 0.0001] and time [F = 368 (1, 64), p < 0.0001] on weight gain. There was also a significant interaction between methamphetamine and time [F = 4.5 (1, 64), p < 0.05] on weight gain. However, methamphetamine alone had no significant effect on heart weight, heart weight / body weight ratio, or weight gain. a p > 0.0001 compared to male 10 day saline; b p < 0.0001 compared to male 10 day methamphetamine; c p < 0.0001 compared to male 10 days saline + 30 days abstinence; d p < 0.0001 compared to female 10 days methamphetamine + 30 days abstinence; e p < 0.0001 compared to female 10 day saline; f p < 0.0001 compared to female 10 days methamphetamine; g p < 0.05 compared to male 10 days saline