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Table 2 Changes in gene expression (2-fold or greater) in female hearts following 10 days methamphetamine treatment. FPKM values represent the mean ± SEM of 5 saline-treated and 6 methamphetamine-treated animals

From: Methamphetamine-induced changes in myocardial gene transcription are sex-dependent

Ensembl Identification

symbol

Gene Name

Saline FPKM

Meth FPKM

Effect (Fold up/ down)

Padj

ENSRNOG00000021027

Dbp*

D-site binding protein

8.2 ± 3.7

76.4 ± 31

9.3 Up

2.1 E-05

ENSRNOG00000050675

Myl4

Myosin Light Chain 4

4.6 ± 1.9

37.4 ± 17

8.2 Down

0.00024

ENSRNOG00000018413

Per3*

Period Circadian Regulator 3

2.1 ± 0.9

17.3 ± 7.1

8.2 Up

9.3 E-06

ENSRNOG00000020254

Per2*

Period Circadian Regulator 2

3.3 ± 1.5

20.3 ± 8.3

6.1 Up

4.0 E-05

ENSRNOG00000014448

Bmal1 / Arntl*

Aryl hydrocarbon receptor nuclear translocator-like protein 1

21.9 ± 9.8

3.9 ± 1.6

5.6 Down

0.019

ENSRNOG00000013408

Npas2*

Neuronal PAS domain protein 2

7.3 ± 3.3

1.7 ± 0.7

4.3 Down

0.0013

ENSRNOG00000000633

Rhobtb1

Rho Related BTB Domain Containing 1

8.7 ± 3.9

37.2 ± 15.2

4.3 Up

5.9E-06

ENSRNOG00000006033

Spon2

Spondin 2

8.3 ± 3.7

2 ± 0.8

4.2 Down

7.5E-05

ENSRNOG00000029980

Zbtb16

Zinc Finger and BTB Domain containing 16

4.8 ± 2.1

18.7 ± 7.6

3.9 Up

0.00033

ENSRNOG00000019383

Tef

Thyrotroph embryonic factor

18 ± 8

62.4 ± 25.5

3.5 Up

8.8E-06

ENSRNOG00000020525

Col5a3

Collagen type V Alpha 3 chain

13.5 ± 6

4 ± 1.6

3.4 Down

5.9E-06

ENSRNOG00000001469

Eln

Elastin

45 ± 20

14 ± 5.7

3.2 Down

2.1E-05

ENSRNOG00000045821

Slc41a3

Solute carrier Family 41 Member 3

57.2 ± 25.6

19.3 ± 7.9

2.963 Down

0.00017

ENSRNOG00000046912

Nr1d2

Nuclear receptor subfamily 1, group D, member 2

11.1 ± 5

30.5 ± 12.4

2.7 Up

0.00017

ENSRNOG00000010947

Mmp14

Matrix metallopeptidase 14

22.9 ± 10.2

8.4 ± 3.4

2.7 Down

1.2E-05

ENSRNOG00000003515

Ephx1

Epoxide hydrolase 1

7.5 ± 3.3

20.2 ± 8.3

2.7 Up

1.5E-05

ENSRNOG00000060511

NA

Neuraminidase

8.8 ± 3.9

23.3 ± 9.5

2.6 Up

2.9E-05

ENSRNOG00000049422

Fcgr2a

Fc fragment of IgG receptor II a

6.5 ± 2.9

2.5 ± 1

2.6 Down

0.0026

ENSRNOG00000000521

Cdkn1a

Cyclin dependent kinase inhibitor 1A

31.8 ± 14.2

12.2 ± 5

2.6 Down

0.00089

ENSRNOG00000046663

Fcgr2a

Fc fragment of IgG receptor II a

11.6 ± 5.2

4.5 ± 1.8

2.6 Down

0.0015

ENSRNOG00000056153

Fam46b

Family with sequence similarity 46, member B

4.8 ± 2.1

11.9 ± 4.9

2.5 Up

0.018

ENSRNOG00000000885

LOC100362819

 

8.9 ± 4

3.6 ± 1.5

2.5 Down

0.00024

ENSRNOG00000001414

Serpin E1

Endothelial plasminogen activator inhibitor-1

7.2 ± 3.2

17.3 ± 7.1

2.4 Up

5.5E-05

ENSRNOG00000029810

Tspan4

Tetraspanin-4

12.1 ± 5.4

29.2 ± 11.9

2.4Up

0.00053

ENSRNOG00000055564

RGD1564664

 

9.5 ± 4.2

4.1 ± 1.7

2.3 Down

0.0019

ENSRNOG00000017716

Ucp3

Mitochondrial uncoupling protein 3

10.5 ± 4.7

4.6 ± 1.9

2.3 Down

0.014

ENSRNOG00000049324

LOC100911766

 

5.5 ± 2.5

12.4 ± 5.1

2.3 Up

0.0005

ENSRNOG00000008680

Loxl1

Lysyl oxidase homolog 1

14.9 ± 6.7

6.7 ± 2.7

2.2 Down

8.6E-05

ENSRNOG00000058500

LOC103694908

 

10.7 ± 4.8

4.9 ± 2.0

2.2 Down

0.015

ENSRNOG00000000906

Medag

Mesenteric estrogen dependent adipogenesis

20 ± 9

9.3 ± 3.8

2.2 Down

7.3E-05

ENSRNOG00000011800

F3

Platelet tissue factor

5.5 ± 2.5

12 ± 5

2.2 Up

0.001

ENSRNOG00000004699

Fibin

Fin Bud Initiation Factor Homolog

9.4 ± 4.2

4.4 ± 1.8

2.1 Down

0.0007

ENSRNOG00000003228

Mid1ip1

MID 1 Interacting Protein 1

31.6 ± 14.1

67.7 ± 27.6

2.1 Up

7.6E-06

ENSRNOG00000006663

Usp2

Ubiquitin Specific Peptidase 2

14.2 ± 6.3

30.1 ± 12.3

2.1 Up

0.015

ENSRNOG00000016573

Dgat2

Diacylglycerol O-Acyltransferase 2

5.8 ± 2.6

12.1 ± 5

2.1 Up

0.0019

ENSRNOG00000005271

Rapgef5

Rap guanine nucleotide exchange factor 5

8.8 ± 3.9

17.6 ± 7.2

2.0 Up

1.2E-05

  1. Effects labeled “up” or “down” indicate methamphetamine-induced increases or decreases in FPKM values of methamphetamine-treated rats compared to saline treated rats. * indicates genes involved in regulating the circadian clock