From: Methamphetamine-induced changes in myocardial gene transcription are sex-dependent
# of Enriched Genes | Category | Description | FDR value |
---|---|---|---|
A. Female Hearts | |||
 12 | NetworkNeighborAL | Circadian rhythm, and PAR basic leucine zipper protein | 3.03E-10 |
 11 | NetworkNeighborAL | Circadian rhythm, and PAR basic leucine zipper protein | 3.18E-10 |
 17 | Reference publications | Analysis of gene regulatory networks in the mammalian circadian rhythm [21] | 7.19E-09 |
 73 | GO Process | negative regulation of cellular process | 9.21E-09 |
 78 | GO Process | negative regulation of biological process | 9.21E-09 |
 62 | GO Process | regulation of biosynthetic process | 9.21E-09 |
 14 | NetworkNeighborAL | mixed, incl. Circadian rhythm, and Basic region leucine zipper | 3.32E-08 |
 42 | GO Process | response to abiotic stimulus | 4.32E-08 |
 13 | NetworkNeighborAL | mixed, incl. Circadian rhythm, and Basic region leucine zipper | 5.19E-08 |
 107 | GO Process | response to stimulus | 6.70E-08 |
 78 | GO Process | response to chemical | 6.70E-08 |
 75 | GO Process | regulation of primary metabolic process | 1.15E-07 |
 94 | GO Function | protein binding | 1.32E-07 |
 152 | GO Process | cellular process | 1.32E-07 |
 57 | GO Process | regulation of cellular biosynthetic process | 1.39E-07 |
 79 | GO Process | regulation of metabolic process | 1.39E-07 |
 39 | GO Process | positive regulation of biosynthetic process | 1.39E-07 |
 8 | NetworkNeighborAL | Circadian rhythm | 1.57E-07 |
 75 | GO Process | regulation of cellular metabolic process | 1.89E-07 |
 116 | GO Process | regulation of cellular process | 2.09E-07 |
B. Male Hearts | |||
 3 | Reactome Pathways | Activation of C3 and C5 | 0.0035 |
 4 | UniProt Keywords | Multifunctional enzyme | 0.0043 |
 23 | UniProt Keywords | Acetylation | 0.0043 |
 38 | UniProt Keywords | Phosphoprotein | 0.0053 |
 6 | Reference publications | Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD) [22] | 0.0098 |
 16 | GO Function | carbohydrate derivative binding | 0.0147 |
 20 | GO Function | anion binding | 0.0147 |
 30 | GO Function | ion binding | 0.0147 |
 10 | GO Function | cytoskeletal protein binding | 0.0147 |
 32 | GO Function | protein binding | 0.0147 |
 47 | GO Function | binding | 0.0147 |
 6 | Reference publications | Recent highlights on bone stem cells: a report from Bone Stem Cells 2009, and not only [23]. | 0...0167 |
 6 | UniProt Keywords | Actin-binding | 0.0176 |
 4 | Reference publications | Transitional Remodeling of the Hepatic Extracellular Matrix in Alcohol-Induced Liver Injury [24] | 0.0187 |
 4 | Reference publications | Influence of culture conditions and extracellular matrix alignment on human mesenchymal stem cells invasion into decellularized engineered tissues [25] | 0.0187 |
 5 | Reference publications | (2014) Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice [26] | 0.0187 |
 17 | UniProt Keywords | Nucleotide-binding | 0.0214 |
 17 | GO Function | small molecule binding | 0.0238 |
 6 | GO Function | actin binding | 0.0238 |
 4 | GO Function | actin filament binding | 0.0275 |