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Table 3 Top 20 functions and pathways (ranked by False Discovery Rate) associated with differentially expressed genes in female (A) or male (B) hearts following 10 days of injection with either methamphetamine or saline

From: Methamphetamine-induced changes in myocardial gene transcription are sex-dependent

# of Enriched Genes

Category

Description

FDR value

A. Female Hearts

 12

NetworkNeighborAL

Circadian rhythm, and PAR basic leucine zipper protein

3.03E-10

 11

NetworkNeighborAL

Circadian rhythm, and PAR basic leucine zipper protein

3.18E-10

 17

Reference publications

Analysis of gene regulatory networks in the mammalian circadian rhythm [21]

7.19E-09

 73

GO Process

negative regulation of cellular process

9.21E-09

 78

GO Process

negative regulation of biological process

9.21E-09

 62

GO Process

regulation of biosynthetic process

9.21E-09

 14

NetworkNeighborAL

mixed, incl. Circadian rhythm, and Basic region leucine zipper

3.32E-08

 42

GO Process

response to abiotic stimulus

4.32E-08

 13

NetworkNeighborAL

mixed, incl. Circadian rhythm, and Basic region leucine zipper

5.19E-08

 107

GO Process

response to stimulus

6.70E-08

 78

GO Process

response to chemical

6.70E-08

 75

GO Process

regulation of primary metabolic process

1.15E-07

 94

GO Function

protein binding

1.32E-07

 152

GO Process

cellular process

1.32E-07

 57

GO Process

regulation of cellular biosynthetic process

1.39E-07

 79

GO Process

regulation of metabolic process

1.39E-07

 39

GO Process

positive regulation of biosynthetic process

1.39E-07

 8

NetworkNeighborAL

Circadian rhythm

1.57E-07

 75

GO Process

regulation of cellular metabolic process

1.89E-07

 116

GO Process

regulation of cellular process

2.09E-07

B. Male Hearts

 3

Reactome Pathways

Activation of C3 and C5

0.0035

 4

UniProt Keywords

Multifunctional enzyme

0.0043

 23

UniProt Keywords

Acetylation

0.0043

 38

UniProt Keywords

Phosphoprotein

0.0053

 6

Reference publications

Fibrosis and progression of autosomal dominant polycystic kidney disease (ADPKD) [22]

0.0098

 16

GO Function

carbohydrate derivative binding

0.0147

 20

GO Function

anion binding

0.0147

 30

GO Function

ion binding

0.0147

 10

GO Function

cytoskeletal protein binding

0.0147

 32

GO Function

protein binding

0.0147

 47

GO Function

binding

0.0147

 6

Reference publications

Recent highlights on bone stem cells: a report from Bone Stem Cells 2009, and not only [23].

0...0167

 6

UniProt Keywords

Actin-binding

0.0176

 4

Reference publications

Transitional Remodeling of the Hepatic Extracellular Matrix in Alcohol-Induced Liver Injury [24]

0.0187

 4

Reference publications

Influence of culture conditions and extracellular matrix alignment on human mesenchymal stem cells invasion into decellularized engineered tissues [25]

0.0187

 5

Reference publications

(2014) Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice [26]

0.0187

 17

UniProt Keywords

Nucleotide-binding

0.0214

 17

GO Function

small molecule binding

0.0238

 6

GO Function

actin binding

0.0238

 4

GO Function

actin filament binding

0.0275