Fig. 8
From: Dense time-course gene expression profiling of the Drosophila melanogaster innate immune response
Diagram describing the process of constructing directed networks from Granger causality. a Lagged correlated expression between two genes (Granger causality) leads to the construction of a directed edge between two genes (nodes), which in turn is used to build directed lead-lag network models of putative interactions among genes. Edges can be positive or negative, based on the sign of lead-lag correlation between the two genes. b Bivariate associations are calculated between two genes at a time, while multivariate associations adjust for potential indirect association from all other genes in the gene set