A) vtg1-KO Experiment: Network stats for proteins down-regulated in vtg1-KO eggs (Wt; N = 32) | |||
number of nodes: | 17 | ||
number of edges: | 18 | ||
average node degree: | 2.12 | ||
clustering coefficient: | 0.64 | ||
expected number of edges: | 6 | ||
PPI enrichment p-value: | 2.75E-05 | ||
confidence level: | 0.15 | ||
KEGG Pathways | |||
pathway | description | protein count | FDR |
dre00330 | Arginine and proline metabolism | 2 of 58 | 0.0074 |
Reactome Pathways | |||
pathway | description | protein count | FDR |
DRE-71288 | Creatine metabolism | 2 of 10 | 0.0001 |
B) vtg1-KO Experiment: Network stats for proteins up-regulated in vtg1-KO eggs (vtg1-KO; N = 94) | |||
number of nodes: | 63 | ||
number of edges: | 107 | ||
average node degree: | 3.4 | ||
clustering coefficient: | 0.387 | ||
expected number of edges: | 58 | ||
PPI enrichment p-value: | 5.95E-09 | ||
confidence level: | 0.40 | ||
KEGG Pathways | |||
pathway | description | protein count | FDR |
dre00270 | Cysteine and methionine metabolism | 3 of 47 | 0.0072 |
dre04260 | Cardiac muscle contraction | 3 of 89 | 0.0135 |
dre04141 | Protein processing in endoplasmic reticulum | 4 of 176 | 0.0135 |
dre01100 | Metabolic pathways | 10 of 1278 | 0.0135 |
dre00790 | Folate biosynthesis | 2 of 26 | 0.0135 |
dre00620 | Pyruvate metabolism | 2 of 41 | 0.0244 |
dre03013 | RNA transport | 3 of 151 | 0.0263 |
dre04261 | Adrenergic signaling in cardiomyocytes | 3 of 180 | 0.0368 |
dre00983 | Drug metabolism - other enzymes | 2 of 61 | 0.0368 |
dre00010 | Glycolysis / Gluconeogenesis | 2 of 74 | 0.0439 |
Reactome Pathways | |||
pathway | description | protein count | FDR |
DRE-71182 | Phenylalanine and tyrosine catabolism | 3 of 14 | 0.003 |
DRE-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 4 of 54 | 0.003 |
DRE-3371568 | Attenuation phase | 3 of 19 | 0.003 |
DRE-3371497 | HSP90 chaperone cycle for steroid hormone receptors | 3 of 21 | 0.003 |
DRE-6798695 | Neutrophil degranulation | 7 of 490 | 0.0088 |
DRE-168256 | Immune System | 11 of 1379 | 0.0154 |
DRE-3371453 | Regulation of HSF1-mediated heat shock response | 3 of 69 | 0.0238 |
DRE-1430728 | Metabolism | 12 of 1751 | 0.0258 |
DRE-2262752 | Cellular responses to stress | 5 of 321 | 0.0313 |
DRE-168249 | Innate Immune System | 8 of 875 | 0.0313 |
DRE-140837 | Intrinsic Pathway of Fibrin Clot Formation | 2 of 19 | 0.0313 |
DRE-140875 | Common Pathway of Fibrin Clot Formation | 2 of 23 | 0.0365 |
DRE-901042 | Calnexin/calreticulin cycle | 2 of 25 | 0.0387 |