Fig. 1

Schematic of our method. a Illustration of the relationship of two gene with protein-protein interaction (PPI) network and gene expression. Genes in gene expression matrix are pre-processed by gene differential expression analysis to select candidate gene subset. The generation of adjacency matrices is by running one or more instance of initial community procedure. Then, the PPI network is combined to the association between genes. bThe gene community is captured by these three models including Independent-Community, Dependent-Community and Merged-Community