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Table 3 Significant canonical pathways identified by IPA involved in the egg-white formation

From: RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen

Ingenuity Canonical Pathways

-log (p-value)

Cell Cycle Control of Chromosomal Replication

11.2

Role of BRCA1 in DNA Damage Response

7.57

Mitotic Roles of Polo-Like Kinase

6.34

Cell Cycle: G2/M DNA Damage Checkpoint Regulation

5.43

Role of CHK Proteins in Cell Cycle Checkpoint Control

5.05

Hereditary Breast Cancer Signaling

4.68

Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I

4.21

Serine Biosynthesis

4.18

Estrogen-mediated S-phase Entry

4.11

DNA Double-Strand Break Repair by Homologous Recombination

3.95

ATM Signaling

3.85

Superpathways of Serine and Glycine Biosynthesis I

3.64

GADD45 Signaling

3.40

DNA damage-induced 14–3-3σ Signaling

3.40

Regulation of Cellular Mechanics by Calpain Protease

3.13

Antiproliferative Role of TOB in T Cell Signaling

2.86

Neuroprotective Role of THOP1 in Alzheimer’s Disease

2.69

Salvage Pathways of Pyrimidine Ribonucleotides

2.64

Atherosclerosis Signaling

2.52

Cyclins and Cell Cycle Regulation

2.43

Dopamine-DARPP32 Feedback in cAMP Signaling

2.38

Complement System

2.28

Inhibition of Matrix Metalloproteases

2.20

Pyridoxal 5′-phosphate Salvage Pathway

2.10

Hepatic Fibrosis / Hepatic Stellate Cell Activation

2.06

Airway Pathology in Chronic Obstructive Pulmonary Disease

2.03

Breast Cancer Regulation by Stathmin1

1.79

Asparagine Biosynthesis I

1.72

Cell Cycle Regulation by BTG Family Proteins

1.54

Mismatch Repair in Eukaryotes

1.44

Asparagine Degradation I

1.42

Choline Degradation I

1.42

eNOS Signaling

1.37

Cardiac β-adrenergic Signaling

1.32

  1. All the differentially expressed genes in the layers were used in Ingenuity Pathway Analysis and significant canonical pathways based on IPA scores were identified. IPA, ingenuity pathway analysis