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Table 2 The major GO annotation terms, Fisher’s p-values and Yekutieli result (FDR under dependency) for the singular enrichment analysis (SEA) of Biological Process, Molecular Function and Cellular Component annotation terms performed on the sperm-surface proteins in the input list

From: Buffalo sperm surface proteome profiling reveals an intricate relationship between innate immunity and reproduction

Biological Process

Molecular Function

Cellular Component

Term

p-value

FDR

Term

p-value

FDR

Term

p-value

FDR

Multicellular organismal process

2.00E-27

1.40E-24

Enzyme binding

2.90E-24

2.90E-22

Membrane-bounded vesicle

5.70E-85

6.10E-83

Sexual reproduction

1.90E-25

6.60E-23

Ubiquitin protein ligase binding

8.20E-16

4.10E-14

Vesicle

5.70E-85

6.10E-83

Reproduction

1.30E-24

3.00E-22

Protein binding

6.00E-11

2.00E-09

Extracellular region part

3.80E-70

2.70E-68

Reproductive process

1.20E-22

2.10E-20

Unfolded protein binding

3.60E-09

9.00E-08

Extracellular region

3.60E-62

1.90E-60

Positive regulation of biological process

1.90E-21

2.70E-19

Protein domain specific binding

1.80E-08

3.50E-07

Cytoplasm

3.90E-32

1.60E-30

Anatomical structure development

4.70E-21

5.50E-19

Carbohydrate binding

8.40E-06

0.00014

Membrane-bounded organelle

1.60E-29

5.70E-28

Regulation of biological quality

4.20E-18

4.20E-16

Binding

0.00037

0.0037

Extracellular space

9.30E-25

2.20E-23

Positive regulation of cellular process

5.30E-18

4.70E-16

Nucleotide binding

0.00041

0.0037

Organelle

1.60E-23

3.50E-22

System development

1.10E-17

8.90E-16

Enzyme regulator activity

0.00041

0.0037

Intracellular part

8.60E-20

1.70E-18

Response to stimulus

5.10E-17

3.60E-15

Catalytic activity

0.0022

0.012

Plasma membrane

7.80E-18

1.30E-16

Cellular developmental process

1.10E-16

7.00E-15

Receptor binding

0.0024

0.012

Cytoplasmic membrane-bounded vesicle

4.80E-15

6.10E-14

Response to biotic stimulus

1.90E-13

5.60E-12

   

Plasma membrane part

5.00E-09

3.90E-08

      

Cell part

4.80E-06

2.60E-05

      

Cell

4.80E-06

2.60E-05