Transcriptomic analysis reveals pronounced changes in gene expression due to sub-lethal pyrethroid exposure and ageing in insecticide resistance Anopheles coluzzii

Table 1 Cytochrome p450s down regulated in 5 day vs 3 day old females. Transcript ID, Gene Name, Adjusted p-value and absolute Fold Change of cytochrome p450s previously implicated in insecticide resistance [14,15,16, 21, 39] in 5-day old adult female mosquitoes compared to 3-day old. Asterisk’s indicates pyrethroid metabolising enzymes [14,15,16]

Transcript ID	Gene Name	Adjusted p-value	Fold Change
AGAP000088-RA	CYP4H19	0.012	0.294
AGAP000818-RA	CYP9K1*	0.013	0.447
AGAP000877-RA	CYP4G17	0.042	0.556
AGAP001076-RA	CYP4G16	0.036	0.634
AGAP001076-RB	CYP4G16	0.050	0.646
AGAP001076-RC	CYP4G16	0.045	0.721
AGAP002862-RA	CYP6AA1	0.049	0.590
AGAP002865-RA	CYP6P3*	0.006	0.379
AGAP002894-RA	CYP6Z4	0.041	0.747
AGAP008212-RA	CYP6M2*	0.004	0.382
AGAP008213-RA	CYP6M3	0.009	0.451
AGAP008214-RA	CYP6M4	0.043	0.739
AGAP008217-RA	CYP6Z3	0.042	0.524
AGAP008218-RA	CYP6Z2*	0.029	0.373
AGAP008219-RA	CYP6Z1	0.008	0.336
AGAP013490-RA	CYP4H24	0.013	0.275

ISSN: 1471-2164