Fig. 2From: Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders MR results for DTI-Disease associations. a: Each radius represents one DTI measures (110 in total: 22 white matter tracts × 5 DTI parameters). From outer to inner layer: -log10(p) for MR-IVW; -log10(p) for MR-Wald Ratio; -log10(p) for intercepts (int.) of MR-Egger regression; heritability of each DTI measures. The dotted grey line indicated the nominal p threshold (0.05); solid grey line indicated study-wide significance p threshold (0.05/1253). CST: Corticospinal tract. b&c: Forest plots showing MR effect of Superior longitudinal fasciculus (axial diusivities) on Anorexia nervosa (SLF.AxD-AN) and body of corpus callosum (fractional anisotropy) on Alzheimer Disease (BDD.FA-AD). Each line showed the single SNP MR effects (95 % confidence interval) estimated by Wald Ratio, and the last line showed the meta-analysis results calculated by IVW. Vertical dashed line indicated the Egger estimation of MR effectBack to article page