Fig. 3

General contribution of DTI polymorphism to neuropsychiatric disorders. a: Quantile-Quantile (QQ) plot showing the distribution of all MR p values for the DTI-Disease (DD) association. b: Disease-specific inflation factor (λ). Solid points showed λ with no adjustment and were corresponded to λ in Table 2. Triangular points showed λ after removal of all DTI-Disorder pairs with significant heterogeneity. Cross points showed λ of p values which were calculated after removing all outlier SNPs (detected by MR-PRESSO) for each DTI-Disorder pair. Vertical error bars indicated a 95 % confidence interval. c: QQ plot for DTI-BP associations. d: Rank-Rank overlaps between MR effect and heterogeneity. The color of each grid corresponded to the proportion of each MR effect rank (each row summed up to 1). The number in each grid showed the exact number of DTI-Disorder pairs. NS: non-significant. Nominal: p < 0.05. SD: Single Disease level significance, p < 0.05/110. SW: Study-Wide significance, p < 0.05/1253