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Table 1 All DTI-Disorder pairs reaching Single Disease significant threshold (p < 0.05 after correction)

From: Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders

disease

DTI

IVW

Egger

Wtd.median

CochranQ

intercept

AN

SLF.AxD

-0.48(6.4 × 10− 6)

-0.02(0.97)

-0.41(0.002)

3.22(0.36)

-0.04(0.52)

AD

BCC.FA

0.07(4.1 × 10− 5)

0.18(0.31)

0.08(3.6 × 10− 4)

2.20(0.70)

-0.007(0.50)

BP

PTR.FA

-0.31(0.0002)

-0.22(0.53)

-0.27(0.008)

2.70(0.44)

-0.010(0.76)

BP

FX.FA

-0.31(0.0003)

0.60(0.30)

-0.27(0.01)

6.60(0.47)

-0.06(0.13)

BP

CGH.MD

0.31(0.0003)

0.11(0.70)

0.29(0.004)

3.13(0.37)

0.02(0.48)

BP

RLIC.RD

0.26(0.0004)

0.11(0.67)

0.22(0.01)

6.92(0.33)

0.01(0.55)

ADHD

ALIC.FA

-0.44(0.0004)

-1.33(0.41)

-0.48(0.001)

2.62(0.27)

0.08(0.53)

  1. Results were shown as estimate (P value). IVW Inverse Variance Weighted sum of Wald Ratio, Wtd.median MR effects estimated by weighted median, Intercept intercept of egger regression, intercept Egger intercept. The definition of DTI acronym are provided in the Method section