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Table 2 Disease-specific p value distribution

From: Mendelian randomization studies of brain MRI yield insights into the pathogenesis of neuropsychiatric disorders

disease

Subregion volume (ROI)

White matter structure (DTI)

lambda

p_ks

lambda

p_ks

AD

1.15(1.07~1.23)

0.92

1.50(1.42~1.58)

0.57

ADHD

1.79(1.74~1.86)

0.21

1.38(1.35~1.41)

0.13

AN

1.20(1.12~1.30)

0.72

1.82(1.73~1.90)

0.14

anxiety

1.04(1.01~1.09)

0.35

0.41(0.40~0.43)

0.0090

ASD

1.08(1.05~1.11)

0.36

1.27(1.23~1.32)

0.021

BP

1.10(1.07~1.15)

0.49

2.64(2.52~2.75)

3.1×10-5

Insomnia

1.42(1.38~1.47)

0.29

0.61(0.59~0.63)

0.061

MD

1.10(1.05~1.16)

0.49

0.60(0.58~0.62)

6.6×10-4

OCD

0.95(0.91~0.99)

0.09

0.68(0.67~0.70)

0.15

PTSD

0.81(0.75~0.89)

0.49

1.51(1.38~1.63)

7.8×10-8

SCZ

1.94(1.90~2)

0.0011

1.21(1.16~1.27)

0.0075

TS

1.02(1.00~1.05)

0.78

1.12(1.08~1.17)

9.3×10-4

  1. Inflation factor (lambda) shown as estimate (95 % confidence interval). p_ks: p value for Komogorov-Smirov test for uniform distribution