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Table 2 DEGs of Clusters 3 and 4: DEGs downregulated in subfertile mares compared to fertile mares

From: A comparative analysis of the intrauterine transcriptome in fertile and subfertile mares using cytobrush sampling

Gene symbol Entrez Gene ID Gene description Human gene symbol log2 FC SUB/FER P-value FDR
ACAP1 100072970 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 ACAP1 −1.01 0.0000 0.0291
ACKR3 100057501 atypical chemokine receptor 3 ACKR3 −1.60 0.0001 0.0474
ADAMTS7 100059959 ADAM metallopeptidase with thrombospondin type 1 motif 7 ADAMTS7 −1.39 0.0001 0.0318
AKR1E2 100070632 aldo-keto reductase family 1 member E2 AKR1E2 −1.93 0.0000 0.0179
ANKRD10 100066458 ankyrin repeat domain 10 ANKRD10 −0.66 0.0007 0.0998
ANO8 100146761 anoctamin 8 ANO8 −1.24 0.0004 0.0763
APBA3 100146445 amyloid beta precursor protein binding family A member 3 APBA3 −0.62 0.0003 0.0708
C1QA 100058097 complement C1q A chain C1QA −0.66 0.0006 0.0861
C1QB 100071667 complement C1q B chain C1QB −0.74 0.0002 0.0562
CEP131 100056159 centrosomal protein 131 CEP131 −0.85 0.0002 0.0529
CIAO3 100065271 cytosolic iron-sulfur assembly component 3 CIAO3 −0.57 0.0007 0.0998
CLK1 100067832 CDC like kinase 1 CLK1 −0.94 0.0004 0.0796
CLK2 100063546 CDC like kinase 2 CLK2 −0.69 0.0006 0.0861
COL16A1 100056083 collagen type XVI alpha 1 chain COL16A1 −1.72 0.0005 0.0847
COL4A1 100066148 collagen type IV alpha 1 chain COL4A1 −1.16 0.0003 0.0658
COL4A2 100066264 collagen type IV alpha 2 chain COL4A2 −1.17 0.0001 0.0354
COL6A1 100050035 collagen type VI alpha 1 chain COL6A1 −1.84 0.0006 0.0897
CYTH4 100069735 cytohesin 4 CYTH4 −0.79 0.0004 0.0798
DENND1C 100065730 DENN domain containing 1C DENND1C −0.91 0.0006 0.0861
DLG4 100061544 discs large MAGUK scaffold protein 4 DLG4 −0.98 0.0003 0.0643
DNASE1L3 100057863 deoxyribonuclease 1 like 3 DNASE1L3 −1.66 0.0001 0.0474
EHBP1L1 100057282 EH domain binding protein 1 like 1 EHBP1L1 −0.93 0.0001 0.0417
ENTPD6 100057043 ectonucleoside triphosphate diphosphohydrolase 6 ENTPD6 −0.70 0.0003 0.0620
FER1L5 100062182 fer-1 like family member 5 FER1L5 −1.77 0.0002 0.0591
FN1 100034189 fibronectin 1 FN1 −2.21 0.0001 0.0472
GRAMD1B 100063638 GRAM domain containing 1B GRAMD1B −0.61 0.0004 0.0763
IRF8 100056218 interferon regulatory factor 8 IRF8 −0.79 0.0005 0.0861
JAK3 100147451 Janus kinase 3 JAK3 −0.66 0.0003 0.0673
KIF7 100069672 kinesin family member 7 KIF7 −0.82 0.0006 0.0867
LAT 100064430 linker for activation of T cells LAT −0.93 0.0001 0.0417
LLGL1 100051856 LLGL1, scribble cell polarity complex component LLGL1 −0.50 0.0006 0.0861
LOC100054029 100054029 leukocyte immunoglobulin-like receptor subfamily A member 5   −1.26 0.0006 0.0883
LOC100054448 100054448 saoe class I histocompatibility antigen, A alpha chain HLA-A −1.26 0.0000 0.0024
LOC100055483 100055483 Ig mu chain C region membrane-bound form-like IGHM −1.82 0.0003 0.0609
LOC100063097 100063097 mitotic-spindle organizing protein 2B-like MZT2B −1.70 0.0001 0.0423
LOC100073089 100073089 ectonucleotide pyrophosphatase/phosphodiesterase family member 3 ENPP3 −1.26 0.0000 0.0200
LOC100629324 100629324 uncharacterized LOC100629324 MEG3 −2.85 0.0001 0.0417
LOC102149846 102149846 immunoglobulin heavy constant gamma 1-like IGHG1 −2.14 0.0005 0.0861
LOC102150085 102150085 immunoglobulin heavy constant gamma 1-like IGHG1 −2.67 0.0000 0.0240
LOC102150790 102150790 uncharacterized LOC102150790   −1.44 0.0000 0.0179
LOC106781059 106781059 uncharacterized LOC106781059   −1.46 0.0001 0.0327
LOC106781303 106781303 immunoglobulin heavy constant alpha 2-like IGHA1 −1.98 0.0005 0.0861
LOC106781940 106781940 uncharacterized LOC106781940   −1.45 0.0004 0.0762
LOC106783330 106783330 uncharacterized LOC106783330   −1.67 0.0001 0.0417
LOC111767520 111767520 uncharacterized LOC111767520   −1.60 0.0003 0.0669
LOC111768661 111768661 translation initiation factor IF-2-like   −1.19 0.0006 0.0897
LOC111768809 111768809 uncharacterized LOC111768809   −2.47 0.0000 0.0113
LOC111771758 111771758 GTPase IMAP family member 5-like   −0.92 0.0001 0.0474
LOC111774331 111774331 uncharacterized LOC111774331   −1.17 0.0003 0.0620
MCF2L 100067048 MCF.2 cell line derived transforming sequence like MCF2L −0.74 0.0001 0.0405
MICAL1 100066627 microtubule associated monooxygenase, calponin and LIM domain containing 1 MICAL1 −0.90 0.0000 0.0263
MMP25 100068942 matrix metallopeptidase 25 MMP25 −1.10 0.0003 0.0619
NAAA 100057831 N-acylethanolamine acid amidase NAAA −1.04 0.0003 0.0642
NUP210L 100056659 nucleoporin 210 like NUP210L −1.11 0.0002 0.0553
PDE10A 100050311 phosphodiesterase 10A PDE10A −2.44 0.0000 0.0195
PLCB2 100057315 phospholipase C beta 2 PLCB2 −0.93 0.0005 0.0861
PLXNA3 100058349 plexin A3 PLXNA3 −1.31 0.0005 0.0861
PREX1 100071328 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 PREX1 −0.68 0.0006 0.0861
RAB44 100629655 RAB44, member RAS oncogene family RAB44 −1.29 0.0005 0.0861
RYR1 100034090 ryanodine receptor 1 RYR1 −1.31 0.0004 0.0737
SLC8B1 100056481 solute carrier family 8 member B1 SLC8B1 −0.66 0.0003 0.0676
SNRNP70 100054907 small nuclear ribonucleoprotein U1 subunit 70 SNRNP70 −0.74 0.0002 0.0591
THBS2 100050044 thrombospondin 2 THBS2 −3.13 0.0000 0.0294
TIA1 100050503 TIA1 cytotoxic granule associated RNA binding protein TIA1 −0.55 0.0006 0.0861
TNNT2 100146343 troponin T2, cardiac type TNNT2 −2.20 0.0001 0.0417
TNXB 100059315 tenascin XB TNXB −1.19 0.0000 0.0240
TOP3B 100051153 DNA topoisomerase III beta TOP3B −0.92 0.0002 0.0602
TPCN2 102150167 two pore segment channel 2 TPCN2 −0.76 0.0002 0.0591
VGLL3 100069930 vestigial like family member 3 VGLL3 −1.41 0.0006 0.0883
WDR90 100066920 WD repeat domain 90 WDR90 −0.75 0.0005 0.0861
ZBP1 100055754 Z-DNA binding protein 1 ZBP1 −0.96 0.0000 0.0294
ZNF333 100064631 zinc finger protein 333 ZNF333 −0.67 0.0007 0.0998