A comparative analysis of the intrauterine transcriptome in fertile and subfertile mares using cytobrush sampling

Weber, Katharina S.; Wagener, Karen; Blanco, Miguel; Bauersachs, Stefan; Bollwein, Heinrich

doi:10.1186/s12864-021-07701-3

BMC Genomics

Table 2 DEGs of Clusters 3 and 4: DEGs downregulated in subfertile mares compared to fertile mares

From: A comparative analysis of the intrauterine transcriptome in fertile and subfertile mares using cytobrush sampling

Gene symbol	Entrez Gene ID	Gene description	Human gene symbol	log2 FC SUB/FER	P-value	FDR
ACAP1	100072970	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	ACAP1	−1.01	0.0000	0.0291
ACKR3	100057501	atypical chemokine receptor 3	ACKR3	−1.60	0.0001	0.0474
ADAMTS7	100059959	ADAM metallopeptidase with thrombospondin type 1 motif 7	ADAMTS7	−1.39	0.0001	0.0318
AKR1E2	100070632	aldo-keto reductase family 1 member E2	AKR1E2	−1.93	0.0000	0.0179
ANKRD10	100066458	ankyrin repeat domain 10	ANKRD10	−0.66	0.0007	0.0998
ANO8	100146761	anoctamin 8	ANO8	−1.24	0.0004	0.0763
APBA3	100146445	amyloid beta precursor protein binding family A member 3	APBA3	−0.62	0.0003	0.0708
C1QA	100058097	complement C1q A chain	C1QA	−0.66	0.0006	0.0861
C1QB	100071667	complement C1q B chain	C1QB	−0.74	0.0002	0.0562
CEP131	100056159	centrosomal protein 131	CEP131	−0.85	0.0002	0.0529
CIAO3	100065271	cytosolic iron-sulfur assembly component 3	CIAO3	−0.57	0.0007	0.0998
CLK1	100067832	CDC like kinase 1	CLK1	−0.94	0.0004	0.0796
CLK2	100063546	CDC like kinase 2	CLK2	−0.69	0.0006	0.0861
COL16A1	100056083	collagen type XVI alpha 1 chain	COL16A1	−1.72	0.0005	0.0847
COL4A1	100066148	collagen type IV alpha 1 chain	COL4A1	−1.16	0.0003	0.0658
COL4A2	100066264	collagen type IV alpha 2 chain	COL4A2	−1.17	0.0001	0.0354
COL6A1	100050035	collagen type VI alpha 1 chain	COL6A1	−1.84	0.0006	0.0897
CYTH4	100069735	cytohesin 4	CYTH4	−0.79	0.0004	0.0798
DENND1C	100065730	DENN domain containing 1C	DENND1C	−0.91	0.0006	0.0861
DLG4	100061544	discs large MAGUK scaffold protein 4	DLG4	−0.98	0.0003	0.0643
DNASE1L3	100057863	deoxyribonuclease 1 like 3	DNASE1L3	−1.66	0.0001	0.0474
EHBP1L1	100057282	EH domain binding protein 1 like 1	EHBP1L1	−0.93	0.0001	0.0417
ENTPD6	100057043	ectonucleoside triphosphate diphosphohydrolase 6	ENTPD6	−0.70	0.0003	0.0620
FER1L5	100062182	fer-1 like family member 5	FER1L5	−1.77	0.0002	0.0591
FN1	100034189	fibronectin 1	FN1	−2.21	0.0001	0.0472
GRAMD1B	100063638	GRAM domain containing 1B	GRAMD1B	−0.61	0.0004	0.0763
IRF8	100056218	interferon regulatory factor 8	IRF8	−0.79	0.0005	0.0861
JAK3	100147451	Janus kinase 3	JAK3	−0.66	0.0003	0.0673
KIF7	100069672	kinesin family member 7	KIF7	−0.82	0.0006	0.0867
LAT	100064430	linker for activation of T cells	LAT	−0.93	0.0001	0.0417
LLGL1	100051856	LLGL1, scribble cell polarity complex component	LLGL1	−0.50	0.0006	0.0861
LOC100054029	100054029	leukocyte immunoglobulin-like receptor subfamily A member 5		−1.26	0.0006	0.0883
LOC100054448	100054448	saoe class I histocompatibility antigen, A alpha chain	HLA-A	−1.26	0.0000	0.0024
LOC100055483	100055483	Ig mu chain C region membrane-bound form-like	IGHM	−1.82	0.0003	0.0609
LOC100063097	100063097	mitotic-spindle organizing protein 2B-like	MZT2B	−1.70	0.0001	0.0423
LOC100073089	100073089	ectonucleotide pyrophosphatase/phosphodiesterase family member 3	ENPP3	−1.26	0.0000	0.0200
LOC100629324	100629324	uncharacterized LOC100629324	MEG3	−2.85	0.0001	0.0417
LOC102149846	102149846	immunoglobulin heavy constant gamma 1-like	IGHG1	−2.14	0.0005	0.0861
LOC102150085	102150085	immunoglobulin heavy constant gamma 1-like	IGHG1	−2.67	0.0000	0.0240
LOC102150790	102150790	uncharacterized LOC102150790		−1.44	0.0000	0.0179
LOC106781059	106781059	uncharacterized LOC106781059		−1.46	0.0001	0.0327
LOC106781303	106781303	immunoglobulin heavy constant alpha 2-like	IGHA1	−1.98	0.0005	0.0861
LOC106781940	106781940	uncharacterized LOC106781940		−1.45	0.0004	0.0762
LOC106783330	106783330	uncharacterized LOC106783330		−1.67	0.0001	0.0417
LOC111767520	111767520	uncharacterized LOC111767520		−1.60	0.0003	0.0669
LOC111768661	111768661	translation initiation factor IF-2-like		−1.19	0.0006	0.0897
LOC111768809	111768809	uncharacterized LOC111768809		−2.47	0.0000	0.0113
LOC111771758	111771758	GTPase IMAP family member 5-like		−0.92	0.0001	0.0474
LOC111774331	111774331	uncharacterized LOC111774331		−1.17	0.0003	0.0620
MCF2L	100067048	MCF.2 cell line derived transforming sequence like	MCF2L	−0.74	0.0001	0.0405
MICAL1	100066627	microtubule associated monooxygenase, calponin and LIM domain containing 1	MICAL1	−0.90	0.0000	0.0263
MMP25	100068942	matrix metallopeptidase 25	MMP25	−1.10	0.0003	0.0619
NAAA	100057831	N-acylethanolamine acid amidase	NAAA	−1.04	0.0003	0.0642
NUP210L	100056659	nucleoporin 210 like	NUP210L	−1.11	0.0002	0.0553
PDE10A	100050311	phosphodiesterase 10A	PDE10A	−2.44	0.0000	0.0195
PLCB2	100057315	phospholipase C beta 2	PLCB2	−0.93	0.0005	0.0861
PLXNA3	100058349	plexin A3	PLXNA3	−1.31	0.0005	0.0861
PREX1	100071328	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	PREX1	−0.68	0.0006	0.0861
RAB44	100629655	RAB44, member RAS oncogene family	RAB44	−1.29	0.0005	0.0861
RYR1	100034090	ryanodine receptor 1	RYR1	−1.31	0.0004	0.0737
SLC8B1	100056481	solute carrier family 8 member B1	SLC8B1	−0.66	0.0003	0.0676
SNRNP70	100054907	small nuclear ribonucleoprotein U1 subunit 70	SNRNP70	−0.74	0.0002	0.0591
THBS2	100050044	thrombospondin 2	THBS2	−3.13	0.0000	0.0294
TIA1	100050503	TIA1 cytotoxic granule associated RNA binding protein	TIA1	−0.55	0.0006	0.0861
TNNT2	100146343	troponin T2, cardiac type	TNNT2	−2.20	0.0001	0.0417
TNXB	100059315	tenascin XB	TNXB	−1.19	0.0000	0.0240
TOP3B	100051153	DNA topoisomerase III beta	TOP3B	−0.92	0.0002	0.0602
TPCN2	102150167	two pore segment channel 2	TPCN2	−0.76	0.0002	0.0591
VGLL3	100069930	vestigial like family member 3	VGLL3	−1.41	0.0006	0.0883
WDR90	100066920	WD repeat domain 90	WDR90	−0.75	0.0005	0.0861
ZBP1	100055754	Z-DNA binding protein 1	ZBP1	−0.96	0.0000	0.0294
ZNF333	100064631	zinc finger protein 333	ZNF333	−0.67	0.0007	0.0998

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ISSN: 1471-2164

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