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Table 3 Functional annotation clusters of the genes found in the global CNVR based on analysis in DAVID

From: Detection of copy number variants in African goats using whole genome sequence data

Cluster (Enrichment score, database) Enrichment term Gene count p-value
1 (1.89, KEGG_PATHWAY) chx04020: Calcium signaling pathway 31 0.001
chx04970: Salivary secretion 16 0.011
chx04022: cGMP-PKG signaling pathway 25 0.016
chx04270: Vascular smooth muscle contraction 19 0.037
chx04261: Adrenergic signaling in cardiomyocytes 21 0.046
2 (1.62, KEGG_PATHWAY) chx04723: Retrograde endocannabinoid signaling 24 0.000
chx04724: Glutamatergic synapse 24 0.000
chx04713: Circadian entrainment 21 0.001
chx04728: Dopaminergic synapse 25 0.002
chx04971: Gastric acid secretion 16 0.004
chx04720: Long-term potentiation 14 0.009
chx04970: Salivary secretion 16 0.011
chx04925: Aldosterone synthesis and secretion 15 0.014
chx04730: Long-term depression 13 0.014
chx04540: Gap junction 16 0.019
chx04750: Inflammatory mediator regulation of TRP channels 18 0.020
chx04921: Oxytocin signaling pathway 23 0.028
chx04922: Glucagon signaling pathway 17 0.028
chx04972: Pancreatic secretion 16 0.033
chx04270: Vascular smooth muscle contraction 19 0.037
chx04725: Cholinergic synapse 18 0.043
chx04911: Insulin secretion 14 0.053
chx04726: Serotonergic synapse 17 0.072
chx04915: Estrogen signaling pathway 15 0.091
chx04961: Endocrine and other factor-regulated calcium reabsorption 8 0.094
chx04912: GnRH signaling pathway 13 0.131
chx04918: Thyroid hormone synthesis 11 0.137
chx04924: Renin secretion 10 0.161
chx04611: Platelet activation 16 0.273
chx04916: Melanogenesis 11 0.458
chx04310: Wnt signaling pathway 14 0.599
3 (1.14, KEGG_PATHWAY) chx05204: Chemical carcinogenesis 12 0.033
chx00980: Metabolism of xenobiotics by cytochrome P450 10 0.075
chx00982: Drug metabolism - cytochrome P450 10 0.075
chx00830: Retinol metabolism 9 0.152