Table 3 Functional annotation clusters of the genes found in the global CNVR based on analysis in DAVID

1 (1.89, KEGG_PATHWAY)

chx04020: Calcium signaling pathway

31

0.001

chx04970: Salivary secretion

16

0.011

chx04022: cGMP-PKG signaling pathway

25

0.016

chx04270: Vascular smooth muscle contraction

19

0.037

chx04261: Adrenergic signaling in cardiomyocytes

21

0.046

2 (1.62, KEGG_PATHWAY)

chx04723: Retrograde endocannabinoid signaling

24

0.000

chx04724: Glutamatergic synapse

24

0.000

chx04713: Circadian entrainment

21

0.001

chx04728: Dopaminergic synapse

25

0.002

chx04971: Gastric acid secretion

16

0.004

chx04720: Long-term potentiation

14

0.009

chx04970: Salivary secretion

16

0.011

chx04925: Aldosterone synthesis and secretion

15

0.014

chx04730: Long-term depression

13

0.014

chx04540: Gap junction

16

0.019

chx04750: Inflammatory mediator regulation of TRP channels

18

0.020

chx04921: Oxytocin signaling pathway

23

0.028

chx04922: Glucagon signaling pathway

17

0.028

chx04972: Pancreatic secretion

16

0.033

chx04270: Vascular smooth muscle contraction

19

0.037

chx04725: Cholinergic synapse

18

0.043

chx04911: Insulin secretion

14

0.053

chx04726: Serotonergic synapse

17

0.072

chx04915: Estrogen signaling pathway

15

0.091

chx04961: Endocrine and other factor-regulated calcium reabsorption

8

0.094

chx04912: GnRH signaling pathway

13

0.131

chx04918: Thyroid hormone synthesis

11

0.137

chx04924: Renin secretion

10

0.161

chx04611: Platelet activation

16

0.273

chx04916: Melanogenesis

11

0.458

chx04310: Wnt signaling pathway

14

0.599

3 (1.14, KEGG_PATHWAY)

chx05204: Chemical carcinogenesis

12

0.033

chx00980: Metabolism of xenobiotics by cytochrome P450

10

0.075

chx00982: Drug metabolism - cytochrome P450

10

0.075

chx00830: Retinol metabolism

9

0.152