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Fig. 4 | BMC Genomics

Fig. 4

From: Comparative neurotranscriptomics reveal widespread species differences associated with bonding

Fig. 4

Vole brain gene expression varies by tissue type. a-c Volcano plots showing significance (−log10(p-value)) and magnitude of difference (log2 fold change, LFC) in expression for each gene. Each point represents a single gene. Orange colored points pass significance threshold of FDR < 0.1. Darker shaded points pass FDR cutoff and have LFC > 2. a Contrast between AMY and HT. Genes with positive LFC values are enriched in AMY, genes with negative LFC values are enriched in HT. b Contrast between AMY and VP/NAc. Genes with positive LFC values are enriched in AMY, genes with negative LFC values are enriched in VP/NAc c Contrast between HT and VP/NAc. Genes with positive LFC values are enriched in HT, genes with negative LFC values are enriched in VP/NAc. d-f Enriched GO terms. Hierarchical clustering tree shows relationship between GO categories based on shared genes. Branches with length of zero are subsets of one another. Fractions preceding GO terms indicate proportion of “good” genes that have raw p-value< 0.05 compared to total number of genes in the category. P-values are corrected using Benjamini-Hochberg false discovery rate procedure [35]. Bold text indicates adjusted p < 0.01, plain text indicates adjusted p < 0.05, and italicized text indicates adjusted p < 0.1 for term. n.s. indicates no significant terms in the category. d Contrast between AMY and HT. Red terms enriched in AMY, blue terms enriched in HT. e Contrast between AMY and VP/NAc. Red terms enriched in AMY, blue terms enriched in VP/NAc. f Contrast between HT and VP/NAc. Red terms enriched in HT, blue terms enriched in VP/NAc

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