Characterization of nucleic acids from extracellular vesicle-enriched human sweat

Bart, Geneviève; Fischer, Daniel; Samoylenko, Anatoliy; Zhyvolozhnyi, Artem; Stehantsev, Pavlo; Miinalainen, Ilkka; Kaakinen, Mika; Nurmi, Tuomas; Singh, Prateek; Kosamo, Susanna; Rannaste, Lauri; Viitala, Sirja; Hiltunen, Jussi; Vainio, Seppo J

doi:10.1186/s12864-021-07733-9

BMC Genomics

Table 5 Bacteriophages identified in sweat DNA

From: Characterization of nucleic acids from extracellular vesicle-enriched human sweat

Protein names	Gene names	Organism	Length
aGPT-Pplase2 domain-containing protein	3 ZEMANAR_3	Mycobacterium phage Zemanar	324
Amidase	ami	Propionibacterium phage PAS10	287
AP2/ERF domain-containing protein	AB9_137	Acinetobacter phage vB_AbaM_B9	262
ATP-dependent helicase	71 SEA_CATERPILLAR_71	Arthrobacter phage Caterpillar	411
ATP-dependent RNA helicase		Pseudoalteromonas phage H103	599
ATPase_AAA_core domain-containing protein	BCP78_0083	Bacillus phage BCP78	358
Baseplate J-like protein	39 SEA_COLUCCI_39	Arthrobacter phage Colucci	373
Beta_helix domain-containing protein	Eldridge_088	Bacillus phage Eldridge	510
Capsid & capsid maturation protease	13 SEA_CATERPILLAR_13	Arthrobacter phage Caterpillar	717
Capsid and capsid maturation protease	13 SEA_MEDIUMFRY_13	Arthrobacter phage MediumFry	717
Capsid and scaffold protein		Propionibacterium phage PA1–14	186
Capsid maturation protease	5 SEA_COLUCCI_5	Arthrobacter phage Colucci	649
Capsid maturation protease	SEA_C3PO_14	Corynebacterium phage C3PO	442
Capsid protein		Staphylococcus phage phiIPLA-C1C	291
Cas4 family exonuclease	SEA_NATOSALEDA_55	Rhodococcus phage Natosaleda	268
CMP deaminase	SEA_WEASELS2_199	Rhodococcus phage Weasels2	118
Collagen-like protein	PHL308M00_19	Propionibacterium phage PHL308M00	268
Collagen-like protein	PHL150M00_19	Propionibacterium phage PHL150M00	268
DNA encapsidation protein	P9AB12kb_p002	Pectobacterium phage DU_PP_III	363
DNA helicase	52 SEA_HOTFRIES_52	Streptomyces phage HotFries	390
DNA helicase	93 PBI_COUNT_93	Microbacterium phage Count	435
DNA helicase	SEA_LUCKYBARNES_64	Brevibacterium phage LuckyBarnes	445
DNA helicase	SEA_MEAK_33	Propionibacterium phage MEAK	317
DNA methylase	65 SEA_MOOMOO_65	Mycobacterium phage MooMoo	542
DNA methylase	61 SEA_NERUJAY_61	Mycobacterium phage Nerujay	365
DNA methylase	SLPG_00003	Salicola phage CGphi29	328
DNA methylase	FLORINDA_85	Mycobacterium phage Florinda	482
DNA methylase	43 GALAXY_43	Arthrobacter phage Galaxy	439
DNA methylase	SEA_YASSJOHNNY_96	Mycobacterium phage YassJohnny	187
DNA methylase	SEA_MURICA_102	Mycobacterium phage Murica	602
DNA methylase	61 PBI_SMEAGOL_61	Mycobacterium phage Smeagol	356
DNA methylase	60 PBI_MUSEUM_60	Mycobacterium virus Museum	465
DNA polymerae/primase	NIKTSON_56	Arthrobacter phage Niktson	1314
DNA polymerase	P9AB12kb_p001	Pectobacterium phage DU_PP_III	690
DNA polymerase I	SEA_LUCKYBARNES_45	Brevibacterium phage LuckyBarnes	621
DNA polymerase III alpha subunit	SEA_DARWIN_47	Corynebacterium phage Darwin	1097
DNA polymerase III alpha subunit	SEA_C3PO_43	Corynebacterium phage C3PO	1097
DNA polymerase/primase	54 SEA_CATERPILLAR_54	Arthrobacter phage Caterpillar	1309
DNA primase	SEA_LUCKYBARNES_63	Brevibacterium phage LuckyBarnes	804
DNA primase	31 P141_31	Propionibacterium phage P14	133
DNA primase	Salvo_71	Xylella phage Salvo	833
DNA primase	Iz_58	Brucella phage Iz	496
DNA primase/polymerase	SEA_C3PO_38	Corynebacterium phage C3PO	847
DNA primase/polymerase	58 SEA_NIGHTMARE_58	Arthrobacter phage Nightmare	1312
DNA single strand annealing protein Erf	uvFWCGRAMDCOMC203_065	Freshwater phage uvFW-CGR-AMD-COM-C203	226
Endolysin	20 P11_20	Propionibacterium phage P1.1	284
Endonuclease	45 SEA_THESTRAL_45	Streptomyces phage Thestral	400
Endonuclease VII	18 SEA_PHISTORY_18	Gordonia phage Phistory	342
Exonuclease	WIZZO_26	Propionibacterium phage Wizzo	348
Exonuclease	MRAK_36	Propionibacterium phage MrAK	313
Exonuclease		Pseudoalteromonas phage H103	292
Gp008	Pepy6gene008	Rhodococcus phage ReqiPepy6	118
Gp067	Pepy6gene067	Rhodococcus phage ReqiPepy6	226
Gp069	Poco6gene069	Rhodococcus phage ReqiPoco6	297
Gp077	Pepy6gene077	Rhodococcus phage ReqiPepy6	193
Gp14	PaP-PAS50_gp14	Propionibacterium phage PAS50	921
Gp16		Propionibacterium phage PA6	385
Gp48	PaP-PAD20_gp48	Propionibacterium phage PAD20	100
H_lectin domain-containing protein	PHL055N00_17	Propionibacterium phage PHL055N00	276
Head protein		Actinomyces virus Av1	455
Head-to-tail adaptor	14 SEA_KYKAR_14	Mycobacterium phage Kykar	125
Head-to-tail connector	12 BARRETLEMON_12	Arthrobacter phage BarretLemon	155
Head-to-tail connector protein	SEA_LILBANDIT_8	Propionibacterium phage LilBandit	115
Helix-turn-helix DNA binding domain protein	132 PBI_COUNT_132	Microbacterium phage Count	927
Helix-turn-helix DNA binding domain protein	78 SEA_LIBERTYBELL_78	Streptomyces phage LibertyBell	910
Helix-turn-helix DNA binding domain protein	PROCRASS1_25	Propionibacterium phage Procrass1	106
Helix-turn-helix DNA binding domain protein	76 PBI_CAMILLE_76	Microbacterium phage Camille	925
Helix-turn-helix DNA binding domain protein	90 SEA_RAINYDAI_90	Streptomyces phage Rainydai	891
Helix-turn-helix DNA binding protein	94 SEA_KEANEYLIN_94	Arthrobacter phage KeaneyLin	891
HNH endonuclease	SEA_SCAP1_2	Streptomyces phage Scap1	135
HNH endonuclease	SEA_ATTOOMI_53	Streptomyces phage Attoomi	101
HNH endonuclease	SKKY_47	Propionibacterium phage SKKY	100
HNH endonuclease	65 SEA_PHAYONCE_65	Mycobacterium phage Phayonce	196
HNH endonuclease		Rhodococcus phage RRH1	91
HNH homing endonuclease		Staphylococcus phage phiIPLA-C1C	269
Holin	MRAK_21	Propionibacterium phage MrAK	133
Homing HNH endonuclase	endo IDF_12	Enterococcus phage Idefix	167
HTH DNA binding protein	58 SEA_BARTHOLOMEW_58	Mycobacterium phage Bartholomew	331
J domain-containing protein	75 SEA_FINCH_75	Rhodococcus phage Finch	194
Lower collar protein		Staphylococcus phage St 134	282
LysM domain protein	18 JAWNSKI_18	Arthrobacter phage Jawnski	221
Major capsid protein	9 MARTHA_9	Arthrobacter phage Martha	295
Major capsid protein	gp79 E3_0790	Rhodococcus phage E3	333
Major capsid subunit	8 JAWNSKI_8	Arthrobacter phage Jawnski	297
Major head protein	PHL141N00_06	Propionibacterium phage PHL141N00	315
Major head protein	mjh	Propionibacterium phage PAD21	314
Major head protein	PHL082M00_06	Propionibacterium phage PHL082M00	323
Major tail protein	16 GORDON_16	Arthrobacter phage Gordon	290
Major tail protein	SEA_DRPARKER_11	Propionibacterium phage DrParker	213
Major tail protein	14 SEA_RAINYDAI_14	Streptomyces phage Rainydai	294
Major tail protein	LAUCHELLY_11	Propionibacterium phage Lauchelly	212
Major tail protein	SEA_C3PO_23	Corynebacterium phage C3PO	220
Major tail sheath	18 PRINCESSTRINA_18	Arthrobacter phage PrincessTrina	482
MazG-like nucleotide pyrophosphohydrolase	41 PBI_PAJAZA_41	Microbacterium phage Pajaza	249
Membrane protein	7 PBI_HYPERION_7	Microbacterium phage Hyperion	238
Membrane protein	26 PBI_POUSHOU_26	Corynebacterium phage Poushou	152
Minor tail protein	SEA_SUPERNOVA_15	Propionibacterium phage Supernova	313
Minor tail protein	SEA_FRANZY_22	Arthrobacter phage Franzy	618
Minor tail protein	SEA_TIMINATOR_21	Arthrobacter phage Timinator	446
Minor tail protein	SEA_AQUARIUS_17	Propionibacterium phage Aquarius	272
Minor tail protein	MRAK_17	Propionibacterium phage MrAK	272
Minor tail protein	SEA_QUEENBEY_16	Propionibacterium phage QueenBey	385
Minor tail subunit	PHL301M00_15	Propionibacterium phage PHL301M00	322
N-acetylmuramoyl-L-alanine amidase domain-containing protein		Propionibacterium phage pa33	286
N-acetylmuramoyl-L-alanine amidase domain-containing protein		Propionibacterium phage pa28	285
Nuclease	SEA_LUCKYBARNES_47	Brevibacterium phage LuckyBarnes	400
p55.1		Xanthomonas virus Xop411	189
PDDEXK_1 domain-containing protein	GMA2_62	Gordonia phage GMA2	331
PDDEXK_1 domain-containing protein	36 P101A_36	Propionibacterium phage P101A	315
Pentapeptide repeat protein	SEP1_136	Staphylococcus phage phiIBB-SEP1	209
Peptidoglycan hydrolase	SEA_BRENT_19	Arthrobacter phage Brent	448
phage terminase, large subunit	g04	Yersinia phage fEV-1	462
POLAc domain-containing protein	GMA2_66	Gordonia phage GMA2	594
Portal	3 P141_3	Propionibacterium phage P14	441
Portal protein	SEA_DRGREY_12	Streptomyces phage DrGrey	450
Portal protein	4 SEA_COLUCCI_4	Arthrobacter phage Colucci	476
Portal protein	KEIKI_3	Propionibacterium phage Keiki	441
Portal protein	SEA_DRPARKER_3	Propionibacterium phage DrParker	441
Portal protein	PHL092M00_03	Propionibacterium phage PHL092M00	441
Portal protein	ArV1_002	Arthrobacter phage vB_ArtM-ArV1	476
Prim-Pol domain-containing protein		Pseudoalteromonas phage H103	761
Putative amidase	PHL060L00_20	Propionibacterium phage PHL060L00	288
Putative bifunctional DNA primase/polymerase	M22_064	Idiomarinaceae phage Phi1M2–2	754
Putative bifunctional DNA primase/polymerase	S708_57	Brucella phage S708	780
Putative capsid	6 P1001_6	Propionibacterium phage P100_1	314
Putative dCTP deaminase	PhAPEC7_24	Escherichia phage vB_EcoP_PhAPEC7	168
Putative DNA helicase	GMA2_64	Gordonia phage GMA2	654
Putative DNA helicase	PHL111M01_33	Propionibacterium phage PHL111M01	317
Putative DNA helicase	PAC5_34	Propionibacterium phage PAC5	287
Putative DNA methyltransferase	55 BRUJITA_55	Mycobacterium virus Brujita	216
Putative DNA primase		Propionibacterium phage PacnesP1	241
Putative DNA primase	PHL111M01_30	Propionibacterium phage PHL111M01	223
Putative DNA primase	PHL085N00_30	Propionibacterium phage PHL085N00	241
Putative DNA primase	PHL111M01_31	Propionibacterium phage PHL111M01	133
Putative endolysin	PHL179M00_20	Propionibacterium phage PHL179M00	296
Putative exonuclease	7S3_41	uncultured Caudovirales phage	281
Putative helicase	Tb_ORF45	Brucella phage Tb	577
Putative major head protein	PHL037M02_06	Propionibacterium phage PHL037M02	316
Putative major tail protein	GMA2_25	Gordonia phage GMA2	139
Putative membrane protein	Twillingate_011	Staphylococcus phage Twillingate	41
Putative phosphoribosyl-ATP pyrophosphohydrolase	SmphiM6_41	Sinorhizobium phage phiM6	129
Putative portal	3 P100D_3	Propionibacterium phage P100D	441
Putative portal protein	PAC4_3	Propionibacterium phage PAC4	406
Putative protease	PHL025M00_16	Propionibacterium phage PHL025M00	385
Putative protease	PHL082M03_16	Propionibacterium phage PHL082M03	385
Putative recA-like NTPase	vBEcoSSa179w3YLVW_00039	Escherichia phage vB_EcoS Sa179lw	274
Putative recA-like NTPase	Sf11_gp7	Shigella phage Sf11 SMD-2017	276
Putative sigma factor	PHL082M03_23	Propionibacterium phage PHL082M03	130
Putative structural protein	GMA2_16	Gordonia phage GMA2	554
Putative structural protein	GMA2_9	Gordonia phage GMA2	584
Putative tape measure	14 P104A_14	Propionibacterium phage P104A	921
Putative tape measure	14 ATCC29399BT_14	Propionibacterium phage ATCC29399B_T	921
Putative tape measure protein	PHL112N00_14	Propionibacterium phage PHL112N00	921
Putative terminase	GMA2_1	Gordonia phage GMA2	559
Putative terminase	PHL111M01_02	Propionibacterium phage PHL111M01	503
Putative terminase large subunit	2 P104A_2	Propionibacterium phage P104A	503
Putative terminase large subunit	ABP12_00064	Acinetobacter phage WCHABP12	433
Putative type III restriction endonuclease	p11sa141_49	Brucella phage 11sa_141	141
Putative VRR-DNA nuclease	M22_057	Idiomarinaceae phage Phi1M2–2	136
Twillingate_149		Staphylococcus phage Twillingate	409
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1)	vBPaeSS218_00016	Pseudomonas phage vB_PaeS_S218	607
Ribonucleotide reductase	SEA_C3PO_3	Corynebacterium phage C3PO	171
Ribonucleotide reductase	SEA_DARWIN_74	Corynebacterium phage Darwin	648
Ribonucleotide reductase large subunit	phiAbaA1_082	Acinetobacter phage vB_AbaM_phiAbaA1	968
Ribonucleotide reductase large subunit (EC 1.17.4.1)	SEP1_061	Staphylococcus phage phiIBB-SEP1	705
RIIA-like protein	153 SEA_ANNADREAMY_153	Streptomyces phage Annadreamy	639
RIIB-like protein	164 SEA_COMRADE_164	Streptomyces phage Comrade	336
RIIB-like protein	SEA_MILDRED21_228	Streptomyces phage Mildred21	326
RNA-binding protein		Streptomyces phage BRock	523
Scaffold protein	PHL179M00_05	Propionibacterium phage PHL179M00	184
Scaffolding protein	SEA_LILBANDIT_5	Propionibacterium phage LilBandit	184
Scaffolding protein	MOYASHI_5	Propionibacterium phage Moyashi	184
Secreted transglycosylase	Quidividi_034	Staphylococcus phage Quidividi	220
SF4 helicase domain-containing protein		Propionibacterium phage pa28	287
Structural protein	Pepy6gene012	Rhodococcus phage ReqiPepy6	115
Structural protein	AB9_053	Acinetobacter phage vB_AbaM_B9	178
Tail assembly chaperone	SEA_C3PO_27	Corynebacterium phage C3PO	273
Tail assembly chaperone	AB9_056	Acinetobacter phage vB_AbaM_B9	131
Tail assembly chaperone	SEA_LEVIOSA_13	Propionibacterium phage Leviosa	227
Tail length tape-measure protein		Propionibacterium phage pa33	921
Tail length tape-measure protein		Propionibacterium phage pa63	921
Tail lysin	SEP1_028	Staphylococcus phage phiIBB-SEP1	1401
Tail lysozyme	30 TAEYOUNG_30	Arthrobacter phage TaeYoung	110
Tail protein	32 BARRETLEMON_32	Arthrobacter phage BarretLemon	427
Tail protein	19 JAWNSKI_19	Arthrobacter phage Jawnski	448
Tail protein		Moraxella phage Mcat20	1460
Tail protein		Staphylococcus phage phiIPLA-C1C	1151
Tail protein	27 PRINCESSTRINA_27	Arthrobacter phage PrincessTrina	645
Tail protein	35 KELLEZIO_35	Arthrobacter phage KellEzio	1704
Tail protein	vB_RpoS-V16_51	Ruegeria phage vB_RpoS-V16	1614
Tail protein		Actinomyces virus Av1	731
Tail sheath	14 JAWNSKI_14	Arthrobacter phage Jawnski	482
Tail sheath	15 MARTHA_15	Arthrobacter phage Martha	482
Tail sheath protein	AB9_051	Acinetobacter phage vB_AbaM_B9	381
Tail sheath protein	SEA_CHOCOLAT_18	Arthrobacter phage Chocolat	482
Tail spike protein	CPT_Mater149	Bacillus phage Mater	663
Tail spike protein	Eldridge_087	Bacillus phage Eldridge	663
Tail-like protein	Shpa_19	Paracoccus phage Shpa	1072
Tape measure protein	PHL141N00_14	Propionibacterium phage PHL141N00	921
Tape measure protein	PHL067M09_14	Propionibacterium phage PHL067M09	921
Tape measure protein	SEA_LUCY_14	Arthrobacter phage Lucy	853
Tape measure protein	PROCRASS1_14	Propionibacterium phage Procrass1	921
Tape measure protein	NIKTSON_26	Arthrobacter phage Niktson	1529
Tape measure protein	AB9_058	Acinetobacter phage vB_AbaM_B9	681
Tape measure protein	22 SEA_CHEESY_22	Arthrobacter phage Cheesy	1492
Tape measure protein	Gsput1_18	Gordonia phage Gsput1	1431
Tape measure protein	PHL082M02_14	Propionibacterium phage PHL082M02	921
Tape measure protein	KEIKI_14	Propionibacterium phage Keiki	921
Tape measure protein	17 SEA_FROKOSTDAME_17	Gordonia phage Frokostdame	1824
Tapemeasure protein	SEA_AQUARIUS_14	Propionibacterium phage Aquarius	921
Terminase	PHL009M11_02	Propionibacterium phage PHL009M11	503
Terminase large subunit	6 SEA_HOTFRIES_6	Streptomyces phage HotFries	581
Terminase large subunit	SEA_TIMINATOR_2	Arthrobacter phage Timinator	489
Terminase large subunit	BiPBO1_02	Brucella phage BiPBO1	562
Terminase large subunit	KEIKI_2	Propionibacterium phage Keiki	503
Terminase large subunit	8 CIRCUM_8	Arthrobacter phage Circum	584
Terminase large subunit	MRAK_2	Propionibacterium phage MrAK	503
Terminase small subunit	BiPBO1_01	Brucella phage BiPBO1	133
Terminase small subunit	3 SEA_MEMENTOMORI_3	Microbacterium phage MementoMori	194
Terminase small subunit	SEA_C3PO_1	Corynebacterium phage C3PO	174
Thioredoxin	SEA_DARWIN_54	Corynebacterium phage Darwin	98
Thymidylate synthase	SEA_ZION_9	Corynebacterium phage Zion	257
Thymidylate synthase	SEA_LUCKYBARNES_41	Brevibacterium phage LuckyBarnes	517
Thymidylate synthase	CB7_206	Pectobacterium phage vB_PatM_CB7	226
Thymidylate synthase	109 PBI_COUNT_109	Microbacterium phage Count	232
Toprim domain-containing protein	30 P100D_30	Propionibacterium phage P100D	223
Transposase	SEP1_056	Staphylococcus phage phiIBB-SEP1	369
Tryptophan synthase beta superfamily protein	2 SEA_ALANGRANT_2	Mycobacterium phage AlanGrant	289

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ISSN: 1471-2164

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