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Fig. 4 | BMC Genomics

Fig. 4

From: Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

Fig. 4

Type-1 interferon pathway of DEGs in P compared to NP samples from day 18 bovine CL clustered by GSEA and IPA. (A) GSEA enrichment plot showing type-1 interferon pathway candidate genes enriched in P compared to NP bovine CL. Normalized enrichment signal (NES); Normalized p-value (NOM), False Discovery Rate (FDR). (B) Type-1 interferon pathway generated with IPA. Genes that are significantly up- and downregulated are shown in red and green, respectively. The intensity of the color corresponds to an increase or decrease in fold change between the P and NP bovine CL. The inset table indicates the expression of select ISGs in CL slices and luteal cells treated with roIFNT (1 ng/mL) in vitro, previously published

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