Fig. 6

Analysis of the TGFB pathway in the P compared to NP bovine CL and the in vitro effect of IFNT in LGCs. (A) Heatmap showing differentially abundant TGFB pathway candidate genes. The heatmap was generated by Morpheus - Broad Institute (https://software.broadinstitute.org/morpheus/). Higher and lower levels of DEGs are denoted in red and blue, respectively, and the median level is denoted in white. The intensity of color corresponds to an increase or decrease in the fold change of the particular DEG. (B) LGCs (n = 4) were treated with either basal media (control) or roIFNT (1 ng/mL) for 24 h. TGFBR1, TGFBR2 and BMP4 expression were measured by qPCR. Asterisks denote significant differences from their controls (***p < 0.001)