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Fig. 2 | BMC Genomics

Fig. 2

From: RNAseq and quantitative proteomic analysis of Dictyostelium knock-out cells lacking the core autophagy proteins ATG9 and/or ATG16

Fig. 2

Differentially regulated proteins (DEPs). (A) Venn diagrams of identified DEPs in ATG9‾ (blue), ATG16‾ (orange), and ATG9‾/16‾ (grey) cells in comparison to AX2 wild-type. Top, up-regulated and bottom, down-regulated DEPs. (B) Presentation of DEPs in a volcano plot for each strain comparison. DEPs with Log2 fold change ≥ 0.262 and p ≤ 0.05 are labelled red, genes with Log2 fold change ≤ − 0.263 and p ≤ 0.05 are labelled blue. The autophagy proteins, ATG8a, ATG8b and Sqstm1, are highlighted by bigger orange-filled circles and DEPs from Table 4, i.e. proteins involved in lipid metabolism, oxidative phosphorylation and ROS clearance, by bigger green-filled circles and labelled with their Demerec names (see Table 4, Gene Product). The plot was created using the R environment (v. 2.15.0)

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BMC Genomics

ISSN: 1471-2164

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