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Fig. 5 | BMC Genomics

Fig. 5

From: Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

Fig. 5

Immunofluorescent staining for CSRP3 and desmin in longitudinal sections of gluteal muscle. Bar = 10 μm. A. Section from a control horse stained with CSRP3 showing a normal pattern of staining. The fluorescent spheres appear to be red blood cells. B. Merged CSRP3 and desmin staining of the same section from a control horse. Nuclei are blue. C. Longitudinal section of an MFM horse stained with CSRP3 taken at the same intensity as the control horse in A. Some, but not all, fibers in the MFM horse had a striated appearance (vertical arrow). D. Merged CSRP3 and desmin staining of the same MFM section in C showing focal regions of the Z disc that had both CSRP3 and desmin staining (vertical arrow). E. Close up view of region under arrow in C showing some striation in the CSRP3 stain. F. Close up view of region under the arrow in D showing colocalization of CSRP3 with desmin in some areas

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BMC Genomics

ISSN: 1471-2164

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