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Fig. 7 | BMC Genomics

Fig. 7

From: Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

Fig. 7

Proposed mechanism causing MFM WB based on DEG, DEP and enrichment analyses. Exercise combined with Z-disc instability in MFM WB induces an increase in PDLIM3, SYNPO3 and CSRP3 protein expression. Nuclear translocation of CSRP3, SYNPO2 and SMTNL1 with TF activation induces gene transcription designed to strengthen the sarcomere. A primary instability in the Z disc or a primary defect in mechanosignaling in MFM WB could lead to inadequate sarcomereogenesis and Z disc repair in MFM WB. A decrease in complex I mitochondrial subunits and enhanced glutathione degradation may be perturbing redox homeostasis with downstream effects of oxidative damage to proteins and aggregation of desmin [43]

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