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Table 1 Significantly DE proteins with a log2 fold change of ≥0.30 in MFM WB compared to control WB

From: Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

Cellular location/ process

Gene ID

Protein

Log2 FC

P adjusted

Function

Detected in transcriptomics

Sarcomere

CSRP3

Cysteine and glycine-rich protein 3

↑0.74

0.002

Z-disc regulator of myogenesis

No

SMTNL1

Smoothelin-like protein 1

↑0.62

<  0.0001

Regulates contractile properties

Yes

MYBPC1

Myosin-binding protein C, slow-type

↑0.46

<  0.0001

Myosin-muscle contraction, creatine kinase binding

Yes

PDLIM3

PDZ and LIM domain protein 3

↑0.34

<  0.0001

Z-disc cytoskeletal organization, maintenance

Yes

SYNPO2

Synaptopodin-2

↑0.34

<  0.0001

Z-disc cytoskeletal organization, maintenance

Yes

TNNT1

Troponin T, slow skeletal muscle

↓0.33

0.0003

Thin filament contractility

Yes

NEB

Nebulin

↓0.31

0.0005

Thin filament integrity

Yes

Cytoskeleton

EML1

Echinoderm microtubule-associated protein-like 1

↑0.35

0.002

microtubule cytoskeleton

Yes

Mitochondria

NDUFV3

NADH dehydrogenase [ubiquinone] flavoprotein 3

↑0.48

0.0007

complex 1 electron transfer

Yes

MTND4

NADH-ubiquinone oxidoreductase chain 4

↓0.52

<  0.0001

complex 1 assembly and catalysis

No

APOO

MICOS complex subunit

↓0.33

0.0024

maintenance of cristae

Yes

Protein processing

HNRNPA1

Heterogeneous nuclear ribonucleoprotein A1

↑0.43

0.0002

mRNA processing

Yes

EEF2K

Eukaryotic elongation factor 2 kinase

↑0.37

0.001

Regulates protein synthesis

Yes

UCHL1

Ubiquitin carboxyl-terminal hydrolase isozyme L1

↑0.34

0.001

Thiol protease- processing of ubiquinated proteins

Yes

EIF3C

Eukaryotic translation initiation factor 3 subunit C

↑0.32

0.0006

mRNA processing

No

BCAP31

B-cell receptor-associated protein 31

↑0.34

0.0005

Protein chaperone

Yes

ASNA1

ATPase ASNA1

↓0.32

0.0006

Post-translational delivery proteins to ER

Yes

Cytoplasm

DDT

D-dopachrome decarboxylase

↑0.61

0.002

D-dopachrome to 5,6-dihydroxyindole

No

CAT

Catalase

↓0.30

0.002

Antioxidant- (cytoplasm, mitochondria and peroxisomes)

Yes

Sarcoplasmic reticulum

TRDN

Triadin

↑0.52

<  0.0001

Calcium release complex

Yes

Sarcolemma

SLMAP

Sarcolemmal membrane-associated protein

↑0.38

<  0.0001

Unfolded protein binding

Yes

Extracellular matrix

CDH13

Cadherin-13

↑0.35

0.0004

Cell-cell adhesion

Yes

Extracellular

HP

Haptoglobin

↑0.52

<  0.0001

preproprotein for haptoglobin- binds hemoglobin

No

FGB

Fibrinogen beta chain

↑0.46

0.001

Inflammation/blood clot

Yes

FGG

Fibrinogen gamma chain

↑0.36

<  0.0001

Inflammation/blood clot

No

FGA

Fibrinogen alpha chain

↑0.34

0.0006

Inflammation/blood clot

No

APOA1

Apolipoprotein A-I

↓0.35

<  0.0001

Cholesterol transport

No