Cellular location/ process | Gene ID | Protein | Log2 FC | P adjusted | Function | Detected in transcriptomics |
---|---|---|---|---|---|---|
Sarcomere | CSRP3 | Cysteine and glycine-rich protein 3 | ↑0.74 | 0.002 | Z-disc regulator of myogenesis | No |
SMTNL1 | Smoothelin-like protein 1 | ↑0.62 | <  0.0001 | Regulates contractile properties | Yes | |
MYBPC1 | Myosin-binding protein C, slow-type | ↑0.46 | <  0.0001 | Myosin-muscle contraction, creatine kinase binding | Yes | |
PDLIM3 | PDZ and LIM domain protein 3 | ↑0.34 | <  0.0001 | Z-disc cytoskeletal organization, maintenance | Yes | |
SYNPO2 | Synaptopodin-2 | ↑0.34 | <  0.0001 | Z-disc cytoskeletal organization, maintenance | Yes | |
TNNT1 | Troponin T, slow skeletal muscle | ↓0.33 | 0.0003 | Thin filament contractility | Yes | |
NEB | Nebulin | ↓0.31 | 0.0005 | Thin filament integrity | Yes | |
Cytoskeleton | EML1 | Echinoderm microtubule-associated protein-like 1 | ↑0.35 | 0.002 | microtubule cytoskeleton | Yes |
Mitochondria | NDUFV3 | NADH dehydrogenase [ubiquinone] flavoprotein 3 | ↑0.48 | 0.0007 | complex 1 electron transfer | Yes |
MTND4 | NADH-ubiquinone oxidoreductase chain 4 | ↓0.52 | <  0.0001 | complex 1 assembly and catalysis | No | |
APOO | MICOS complex subunit | ↓0.33 | 0.0024 | maintenance of cristae | Yes | |
Protein processing | HNRNPA1 | Heterogeneous nuclear ribonucleoprotein A1 | ↑0.43 | 0.0002 | mRNA processing | Yes |
EEF2K | Eukaryotic elongation factor 2 kinase | ↑0.37 | 0.001 | Regulates protein synthesis | Yes | |
UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | ↑0.34 | 0.001 | Thiol protease- processing of ubiquinated proteins | Yes | |
EIF3C | Eukaryotic translation initiation factor 3 subunit C | ↑0.32 | 0.0006 | mRNA processing | No | |
BCAP31 | B-cell receptor-associated protein 31 | ↑0.34 | 0.0005 | Protein chaperone | Yes | |
ASNA1 | ATPase ASNA1 | ↓0.32 | 0.0006 | Post-translational delivery proteins to ER | Yes | |
Cytoplasm | DDT | D-dopachrome decarboxylase | ↑0.61 | 0.002 | D-dopachrome to 5,6-dihydroxyindole | No |
CAT | Catalase | ↓0.30 | 0.002 | Antioxidant- (cytoplasm, mitochondria and peroxisomes) | Yes | |
Sarcoplasmic reticulum | TRDN | Triadin | ↑0.52 | <  0.0001 | Calcium release complex | Yes |
Sarcolemma | SLMAP | Sarcolemmal membrane-associated protein | ↑0.38 | <  0.0001 | Unfolded protein binding | Yes |
Extracellular matrix | CDH13 | Cadherin-13 | ↑0.35 | 0.0004 | Cell-cell adhesion | Yes |
Extracellular | HP | Haptoglobin | ↑0.52 | <  0.0001 | preproprotein for haptoglobin- binds hemoglobin | No |
FGB | Fibrinogen beta chain | ↑0.46 | 0.001 | Inflammation/blood clot | Yes | |
FGG | Fibrinogen gamma chain | ↑0.36 | <  0.0001 | Inflammation/blood clot | No | |
FGA | Fibrinogen alpha chain | ↑0.34 | 0.0006 | Inflammation/blood clot | No | |
APOA1 | Apolipoprotein A-I | ↓0.35 | <  0.0001 | Cholesterol transport | No |