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Table 1 Significantly DE proteins with a log2 fold change of ≥0.30 in MFM WB compared to control WB

From: Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

Cellular location/ process Gene ID Protein Log2 FC P adjusted Function Detected in transcriptomics
Sarcomere CSRP3 Cysteine and glycine-rich protein 3 ↑0.74 0.002 Z-disc regulator of myogenesis No
SMTNL1 Smoothelin-like protein 1 ↑0.62 <  0.0001 Regulates contractile properties Yes
MYBPC1 Myosin-binding protein C, slow-type ↑0.46 <  0.0001 Myosin-muscle contraction, creatine kinase binding Yes
PDLIM3 PDZ and LIM domain protein 3 ↑0.34 <  0.0001 Z-disc cytoskeletal organization, maintenance Yes
SYNPO2 Synaptopodin-2 ↑0.34 <  0.0001 Z-disc cytoskeletal organization, maintenance Yes
TNNT1 Troponin T, slow skeletal muscle ↓0.33 0.0003 Thin filament contractility Yes
NEB Nebulin ↓0.31 0.0005 Thin filament integrity Yes
Cytoskeleton EML1 Echinoderm microtubule-associated protein-like 1 ↑0.35 0.002 microtubule cytoskeleton Yes
Mitochondria NDUFV3 NADH dehydrogenase [ubiquinone] flavoprotein 3 ↑0.48 0.0007 complex 1 electron transfer Yes
MTND4 NADH-ubiquinone oxidoreductase chain 4 ↓0.52 <  0.0001 complex 1 assembly and catalysis No
APOO MICOS complex subunit ↓0.33 0.0024 maintenance of cristae Yes
Protein processing HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1 ↑0.43 0.0002 mRNA processing Yes
EEF2K Eukaryotic elongation factor 2 kinase ↑0.37 0.001 Regulates protein synthesis Yes
UCHL1 Ubiquitin carboxyl-terminal hydrolase isozyme L1 ↑0.34 0.001 Thiol protease- processing of ubiquinated proteins Yes
EIF3C Eukaryotic translation initiation factor 3 subunit C ↑0.32 0.0006 mRNA processing No
BCAP31 B-cell receptor-associated protein 31 ↑0.34 0.0005 Protein chaperone Yes
ASNA1 ATPase ASNA1 ↓0.32 0.0006 Post-translational delivery proteins to ER Yes
Cytoplasm DDT D-dopachrome decarboxylase ↑0.61 0.002 D-dopachrome to 5,6-dihydroxyindole No
CAT Catalase ↓0.30 0.002 Antioxidant- (cytoplasm, mitochondria and peroxisomes) Yes
Sarcoplasmic reticulum TRDN Triadin ↑0.52 <  0.0001 Calcium release complex Yes
Sarcolemma SLMAP Sarcolemmal membrane-associated protein ↑0.38 <  0.0001 Unfolded protein binding Yes
Extracellular matrix CDH13 Cadherin-13 ↑0.35 0.0004 Cell-cell adhesion Yes
Extracellular HP Haptoglobin ↑0.52 <  0.0001 preproprotein for haptoglobin- binds hemoglobin No
FGB Fibrinogen beta chain ↑0.46 0.001 Inflammation/blood clot Yes
FGG Fibrinogen gamma chain ↑0.36 <  0.0001 Inflammation/blood clot No
FGA Fibrinogen alpha chain ↑0.34 0.0006 Inflammation/blood clot No
APOA1 Apolipoprotein A-I ↓0.35 <  0.0001 Cholesterol transport No