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Table 2 Significantly DE annotated genes with a log2 FC > 2 in MFM WB compared to control WB

From: Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

Function Gene ID Gene log2 FC P adjusted Function Detected in proteomics
Transcription factors CCR7 C-C Motif Chemokine Receptor 7 ↑3.4 0.02 Lymphocyte activation no
NR4A2 Nuclear receptor subfamily 4 group A member 2 ↑2.9 0.031 Steroid-thyroid hormone-retinoid receptor no
GADD45G Growth Arrest and DNA Damage Inducible Gamma ↑2.6 0.014 Response to environmental stresses no
ATF3 Cyclic AMP-dependent transcription factor ATF-3 ↑2.5 0.05 Cellular stress response no
CEBPD CCAAT/enhancer-binding protein delta ↑2.5 0.009 Immune and inflammatory responses, myostatin no
Thiol-dependent CHAC1 Glutathione-specific gamma-glutamylcyclotransferase 1 ↑4.8 0.006 Glutathione degradation, apoptosis, Notch signaling no
OTUD1 OTU domain-containing protein 1 ↑2.8 0.021 Thiol-dependent ubiquitin-specific protease activity no
Immune response ADAMDEC1 ADAM Like Decysin 1 ↓3.5 0.021 Disintegrin metalloproteinase no
Cell-cell interactions THBS1 Thrombospondin ↑2.7 0.007 Blood clot formation, inhibits angiogenesis no
Erythrocyte AMPD3 AMP deaminase 3 ↑2.6 <  0.0001 Deaminase activity (erythrocyte form) no
HBB Hemoglobin subunit beta ↓6.7 0.019 Oxygen and iron binding yes not DEP