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Table 2 Significantly DE annotated genes with a log2 FC > 2 in MFM WB compared to control WB

From: Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

Function

Gene ID

Gene

log2 FC

P adjusted

Function

Detected in proteomics

Transcription factors

CCR7

C-C Motif Chemokine Receptor 7

↑3.4

0.02

Lymphocyte activation

no

NR4A2

Nuclear receptor subfamily 4 group A member 2

↑2.9

0.031

Steroid-thyroid hormone-retinoid receptor

no

GADD45G

Growth Arrest and DNA Damage Inducible Gamma

↑2.6

0.014

Response to environmental stresses

no

ATF3

Cyclic AMP-dependent transcription factor ATF-3

↑2.5

0.05

Cellular stress response

no

CEBPD

CCAAT/enhancer-binding protein delta

↑2.5

0.009

Immune and inflammatory responses, myostatin

no

Thiol-dependent

CHAC1

Glutathione-specific gamma-glutamylcyclotransferase 1

↑4.8

0.006

Glutathione degradation, apoptosis, Notch signaling

no

OTUD1

OTU domain-containing protein 1

↑2.8

0.021

Thiol-dependent ubiquitin-specific protease activity

no

Immune response

ADAMDEC1

ADAM Like Decysin 1

↓3.5

0.021

Disintegrin metalloproteinase

no

Cell-cell interactions

THBS1

Thrombospondin

↑2.7

0.007

Blood clot formation, inhibits angiogenesis

no

Erythrocyte

AMPD3

AMP deaminase 3

↑2.6

<  0.0001

Deaminase activity (erythrocyte form)

no

HBB

Hemoglobin subunit beta

↓6.7

0.019

Oxygen and iron binding

yes not DEP