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Fig. 1 | BMC Genomics

Fig. 1

From: Exome-based investigation of the genetic basis of human pigmentary glaucoma

Fig. 1

MRAP immunoreactivity in the human eye. A section of anterior segment from a human eye was immunolabeled (top row) with anti-MRAP antibody (red) and anti-collagen IV antibody (green). Nuclei were stained with DAPI (blue). MRAP immunoreactivity was observed throughout anterior segment structures, including the iris, trabecular meshwork (TM), ciliary processes (CP) and cornea. Immunopositive cells were observed on the anterior surface of the iris, throughout the iris stroma, and on the posterior aspect of the basement membrane (BM). Strong immunoreactivity was also exhibited by trabecular meshwork cells, including the endothelial lining of Schlemm’s canal (SC). Epithelial cells of ciliary processes and corneal epithelium and endothelium were also immunopositive. A section from the same eye was treated identically but without the addition of primary antibodies to serve as a control for non-specific labeling by secondary antibodies (bottom row)

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