Skip to main content

Table 1 Clinical features of PDS and control patient cohorts from Iowa

From: Exome-based investigation of the genetic basis of human pigmentary glaucoma

  PDS cohort Control cohort
n = 210 n = 362
Agea 59.6 ± 13.5 61.1 ± 20.2
Gender (female %) 33.8% 56.4%
Self-reported race / ethnicity2
 White (European ancestry) 97.55% 97.60%
 Black (African ancestry)3 0.98% 0.60%
 Hispanic 0.49% 0%
 Asian (Chinese) 0.49% 0.60%
 Native American / Alaskan 0.49% 1.2%
Signs of PDS detected
 Krukenberg spindle 175 (83%)  
 Heavy pigmentation of trabecular meshwork 198 (94%)  
 Iris transillumination defects 180 (86%)  
 Scheie stripe 35 (17%)  
Diagnosis
 PDS suspect 5 (2.4%)  
 PDS 26 (12.4%)  
 PDS with OHT 21 (10%)  
 Pigmentary glaucoma with OHT 148 (70%)  
 Pigmentary glaucoma without OHT 3 (1.4%)  
 Other (excluded from analysis) 7 (3.3%)  
Genetics study participants
 Total enrolled 210 362
  Excluded for incomplete clinical records 7 0
  Excluded for relatedness to another subject 1 1
  Excluded for a secondary cause of pigment release 2 0
  Excluded as outliers based on PCA 2 2
 Total investigated with genetic studies 198 359
  1. aAge is at the time of blood draw and was available for n = 190 PDS patients (90%) and n = 348 control subjects (96%). 2Self-reported race/ethnicity was available from 97% of cases and 46% of controls. 3Subsequently eliminated from the study as outliers on principal components analysis. Abbreviations in the table are: ocular hypertension (OHT)