From: Exome-based investigation of the genetic basis of human pigmentary glaucoma
 | PDS cohort | Control cohort |
---|---|---|
n = 210 | n = 362 | |
Agea | 59.6 ± 13.5 | 61.1 ± 20.2 |
Gender (female %) | 33.8% | 56.4% |
Self-reported race / ethnicity2 | ||
 White (European ancestry) | 97.55% | 97.60% |
 Black (African ancestry)3 | 0.98% | 0.60% |
 Hispanic | 0.49% | 0% |
 Asian (Chinese) | 0.49% | 0.60% |
 Native American / Alaskan | 0.49% | 1.2% |
Signs of PDS detected | ||
 Krukenberg spindle | 175 (83%) |  |
 Heavy pigmentation of trabecular meshwork | 198 (94%) |  |
 Iris transillumination defects | 180 (86%) |  |
 Scheie stripe | 35 (17%) |  |
Diagnosis | ||
 PDS suspect | 5 (2.4%) |  |
 PDS | 26 (12.4%) |  |
 PDS with OHT | 21 (10%) |  |
 Pigmentary glaucoma with OHT | 148 (70%) |  |
 Pigmentary glaucoma without OHT | 3 (1.4%) |  |
 Other (excluded from analysis) | 7 (3.3%) |  |
Genetics study participants | ||
 Total enrolled | 210 | 362 |
  Excluded for incomplete clinical records | 7 | 0 |
  Excluded for relatedness to another subject | 1 | 1 |
  Excluded for a secondary cause of pigment release | 2 | 0 |
  Excluded as outliers based on PCA | 2 | 2 |
 Total investigated with genetic studies | 198 | 359 |