Skip to main content

Table 1 Gene Ontology analysis based on Pc data. Genes having Pc < − 0.2 were considered. For cumulative Pc analysis, the 3 individual Pc were added and the genes within the 5th percentile of those with higher cumulative Pc were considered

From: Transcriptomic coordination at hepatic steatosis indicates robust immune cell engagement prior to inflammation

GO biological process complete

Fold Enrichment

raw P-value

FDR

Steatosis vs Control

 positive regulation of chemokine (C-X-C motif) ligand 2 production (GO:2000343)

11.63

2.14E-04

4.27E-02

 myeloid leukocyte activation (GO:0002274)

3.33

6.62E-05

2.01E-02

 myeloid leukocyte differentiation (GO:0002573)

3.28

2.14E-04

4.32E-02

 positive regulation of T cell activation (GO:0050870)

3.21

3.26E-06

2.71E-03

 cytokine production (GO:0001816)

3.08

9.61E-05

2.40E-02

 positive regulation of leukocyte cell-cell adhesion (GO:1903039)

3.02

5.30E-06

2.98E-03

 positive regulation of leukocyte proliferation (GO:0070665)

2.94

2.50E-04

4.75E-02

 cell activation involved in immune response (GO:0002263)

2.7

2.75E-04

4.97E-02

 regulation of T cell activation (GO:0050863)

2.69

2.12E-06

1.97E-03

 regulation of leukocyte cell-cell adhesion (GO:1903037)

2.67

3.55E-06

2.66E-03

Non steatosis vs Control

 neuronal action potential propagation (GO:0019227)

13.51

1.17E-04

4.49E-02

 action potential propagation (GO:0098870)

13.51

1.17E-04

4.38E-02

 plasma membrane organization (GO:0007009)

3.82

8.77E-05

3.63E-02

 lymphocyte differentiation (GO:0030098)

2.66

1.60E-05

1.09E-02

 mononuclear cell differentiation (GO:1903131)

2.46

4.78E-05

2.28E-02

 leukocyte differentiation (GO:0002521)

2.36

3.51E-05

1.84E-02

 lymphocyte activation (GO:0046649)

2.35

9.87E-06

7.77E-03

 leukocyte activation (GO:0045321)

2.22

5.65E-06

5.56E-03

 hemopoiesis (GO:0030097)

2.1

3.73E-06

5.33E-03

 hematopoietic or lymphoid organ development (GO:0048534)

1.97

1.44E-05

1.08E-02

Steatosis vs Non-Steatosis

 mitotic G2/M transition checkpoint (GO:0044818)

6

6.01E-05

2.70E-02

 negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)

5.24

6.31E-05

2.68E-02

 negative regulation of cell cycle G2/M phase transition (GO:1902750)

4.68

6.85E-05

2.77E-02

 regulation of G2/M transition of mitotic cell cycle (GO:0010389)

4.64

1.79E-06

1.76E-03

 regulation of cell cycle G2/M phase transition (GO:1902749)

3.9

1.26E-05

8.61E-03

 negative regulation of mitotic cell cycle phase transition (GO:1901991)

3.15

7.98E-05

3.14E-02

 negative regulation of cell cycle phase transition (GO:1901988)

3.12

3.47E-05

1.89E-02

 regulation of mitotic cell cycle phase transition (GO:1901990)

2.79

1.79E-06

1.66E-03

 regulation of cell cycle phase transition (GO:1901987)

2.56

8.13E-06

6.40E-03

 mitotic cell cycle (GO:0000278)

2.06

1.73E-05

1.09E-02

Pc (cumulative) with top 5% of genes (600)

 mammary gland epithelium development (GO:0061180)

5.14

1.34E-04

4.91E-02

 cellular modified amino acid metabolic process (GO:0006575)

3.59

2.51E-05

1.36E-02

 sulfur compound metabolic process (GO:0006790)

2.95

9.59E-06

5.59E-03

 glycerophospholipid metabolic process (GO:0006650)

2.76

1.29E-04

4.85E-02

 phospholipid metabolic process (GO:0006644)

2.59

6.53E-05

2.94E-02

 cellular lipid metabolic process (GO:0044255)

2.4

5.38E-09

9.41E-06

 organophosphate metabolic process (GO:0019637)

2.37

1.09E-07

1.07E-04

 monocarboxylic acid metabolic process (GO:0032787)

2.26

6.99E-05

3.06E-02

 carboxylic acid metabolic process (GO:0019752)

2.19

2.63E-06

1.80E-03

 organic acid metabolic process (GO:0006082)

2.18

1.16E-06

9.65E-04