Fig. 5
From: A functional map of genomic HIF1α-DNA complexes in the eye lens revealed through multiomics analysis
Integrated CUT&RUN and RNA-seq analysis identifies previously established and novel HIF1α-dependent lens targets. A Heatmap of significantly upregulated (log2FC > 0.7, p < 0.05) and downregulated (log2FC < − 0.7, p < 0.05) genes with a HIF1α-DNA binding complex that are known to be regulated by hypoxia from [57]. Level of Red indicates higher gene expression levels, and level of blue indicates lower gene expression levels. B Heatmap of significantly upregulated (log2FC > 0.7, p < 0.05) and downregulated (log2FC < − 0.7, p < 0.05) genes with a HIF1α-DNA binding complex that are not previously known to be regulated by hypoxia from [57]. Red indicates higher gene expression levels, and blue indicates lower gene expression levels