Fig. 2
From: Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss
Analysis of the α-cell dynamic transcriptional response to β-cell loss reveals signaling pathways potentially modulating α-cell conversion towards insulin production. Selected Gene Set Enrichment Analysis (GSEA) results are presented (see also Figure S2). Genes with higher expression in 5dpDT α-cells, relative to its timely connected stages (Ctrl and 15dpDT α-cells) are associated with interferon signaling and control of the mitotic process. Genes downregulated in 15dpDT α-cells, relative to its timely connected stages (5dpDT and 30dpDT α-cells) are associated with inhibition of signaling from InsR, mTOR and MET pathways. All results presented are significant, considering a P-value < 0.05 and FDR < 0.25