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Table 1 Canonical pathways enriched by DEGs comparing Con and LP groups of LSL laying hens and LCaP and LP of LB laying hens

From: Transcriptional responses in jejunum of two layer chicken strains following variations in dietary calcium and phosphorus levels

Canonical pathways padj-value z-score* Molecules
Lohmann Selected Leghorn (LSL): Con vs. LP
EIF2 Signaling < 0.001 3.00 AKT1,ATF3,EIF3K,FAU,KRAS,PAIP1,PIK3C2A,PIK3CG,
RPL10A,RPL11,RPL12,RPL13,RPL21,RPL22,RPL23,RPL27A,
RPL3,RPL30,RPL31,RPL32,RPL34,RPL35,RPL36,RPLP0,
RPLP1,RPS10,RPS11,RPS15,RPS16,RPS17,RPS19,RPS20,
RPS23,RPS3,RPS4X,RPS6,UBA52,XIAP
Regulation of eIF4 and p70S6K Signaling < 0.001 -1.89 AKT1,EIF3K,EIF4EBP2,FAU,KRAS,MTOR,PAIP1,PIK3C2A,
PIK3CG,RPS10,RPS11,RPS15,RPS16,RPS17,RPS19,
RPS20,RPS23,RPS3,RPS4X,RPS6,RPS6KB1
mTOR Signaling 0.005 -1.89 AKT1,EIF3K,FAU,KRAS,MTOR,PIK3C2A,PIK3CG,PRR5L,
RPS10,RPS11,RPS15,RPS16,RPS17,RPS19,RPS20,RPS23,
RPS3,RPS4X,RPS6,RPS6KB1
IL-4 Signaling 0.013   AKT1,JAK2,KRAS,MTOR,NFAT5,NFATC3,NR3C2,
PIK3C2A,PIK3CG,RPS6KB1,SOCS1
Glucocorticoid Receptor Signaling 0.034   AKT1,BAG1,GTF2A1,GTF2H1,JAK2,KAT2B,KRAS,MAPK9,
MED14,NCOA2,NFAT5,NFATC3,NR3C2,PIK3C2A,PIK3CG,
POLR2E,POLR2L,PPP3CA,TAF4,TGFB1,YWHAH
Lohmann Brown (LB): LCaP vs. LP    
Agranulocyte Adhesion and Diapedesis < 0.001   ACTA2,CCL23,CD34,CDH5,CLDN10,CLDN2,CXCL12,
CXCL14,FN1,JAM3,MMP10,MMP11,MMP17,MMP2,
MMP9,MYH11,MYL4,MYL9,PODXL,PPBP,TNFRSF1A
Granulocyte Adhesion and Diapedesis < 0.001   CCL23,CDH5,CLDN10,CLDN2,CXCL12,CXCL14,JAM3,
MMP10,MMP11,MMP17,MMP2,MMP9,PPBP,SDC2,
SDC3,THY1,TNFRSF1A
GP6 Signaling Pathway < 0.001 3.77 COL13A1,COL16A1,COL18A1,COL1A1,COL1A2,COL3A1,
COL4A1,COL4A2,COL4A6,COL5A1,COL5A2,COL6A1,
COL6A2,COL6A3,LAMA1,LAMB1,LAMB3,NOX1
Axonal Guidance Signaling < 0.001   ADAM19,ADAMTS1,ADAMTS13,ADAMTS9,BMP4,BMP6,
CFL2,CXCL12,ECEL1,EFNB1,EPHB2,FZD6,GNB1L,HHIP,
LINGO1,MMP10,MMP11,MMP17,MMP2,MMP9,MYL4,
MYL9,NRP2,NTN3,NTN4,PDGFD,PLCD3,PLXND1,PTCH2,
RASD2,SDC2,SEMA3F,TUBA4A,UNC5B,UNC5C,WNT2B,
WNT4
Inhibition of Matrix Metalloproteases < 0.001 -1.13 HSPG2,MMP10,MMP11,MMP17,MMP2,MMP9,SDC2,
TFPI2,TIMP2
Apelin Liver Signaling Pathway 0.002 2.45 COL18A1,COL1A1,COL1A2,COL3A1,IRS1,PDGFRB
Intrinsic Prothrombin Activation Pathway 0.014 1.34 COL18A1,COL1A1,COL1A2,COL3A1,PROS1
Inhibition of Angiogenesis by TSP1 0.029 0.00 CD36,HSPG2,MMP9,NOS3,SDC2,THBS1
Leukocyte Extravasation Signaling 0.044 1.90 ACTA2,CDH5,CLDN10,CLDN2,CXCL12,CYBB,JAM3,MMP10,
MMP11,MMP17,MMP2,MMP9,NOX1,THY1,TIMP2
  1. * z-score: pathways with an absolute z-score ≥ 2 were considered significant. Positive and negative values indicate activation (in LSL: LP > Con; in LB: LCaP > LP) and inhibition (in LSL: LP < Con; in LB: LCaP < P)