Table 1 Canonical pathways enriched by DEGs comparing Con and LP groups of LSL laying hens and LCaP and LP of LB laying hens

Lohmann Selected Leghorn (LSL): Con vs. LP

EIF2 Signaling

< 0.001

3.00

AKT1,ATF3,EIF3K,FAU,KRAS,PAIP1,PIK3C2A,PIK3CG,

RPL10A,RPL11,RPL12,RPL13,RPL21,RPL22,RPL23,RPL27A,

RPL3,RPL30,RPL31,RPL32,RPL34,RPL35,RPL36,RPLP0,

RPLP1,RPS10,RPS11,RPS15,RPS16,RPS17,RPS19,RPS20,

RPS23,RPS3,RPS4X,RPS6,UBA52,XIAP

Regulation of eIF4 and p70S6K Signaling

< 0.001

-1.89

AKT1,EIF3K,EIF4EBP2,FAU,KRAS,MTOR,PAIP1,PIK3C2A,

PIK3CG,RPS10,RPS11,RPS15,RPS16,RPS17,RPS19,

RPS20,RPS23,RPS3,RPS4X,RPS6,RPS6KB1

mTOR Signaling

0.005

-1.89

AKT1,EIF3K,FAU,KRAS,MTOR,PIK3C2A,PIK3CG,PRR5L,

RPS10,RPS11,RPS15,RPS16,RPS17,RPS19,RPS20,RPS23,

RPS3,RPS4X,RPS6,RPS6KB1

IL-4 Signaling

0.013

AKT1,JAK2,KRAS,MTOR,NFAT5,NFATC3,NR3C2,

PIK3C2A,PIK3CG,RPS6KB1,SOCS1

Glucocorticoid Receptor Signaling

0.034

AKT1,BAG1,GTF2A1,GTF2H1,JAK2,KAT2B,KRAS,MAPK9,

MED14,NCOA2,NFAT5,NFATC3,NR3C2,PIK3C2A,PIK3CG,

POLR2E,POLR2L,PPP3CA,TAF4,TGFB1,YWHAH

Lohmann Brown (LB): LCaP vs. LP

Agranulocyte Adhesion and Diapedesis

< 0.001

ACTA2,CCL23,CD34,CDH5,CLDN10,CLDN2,CXCL12,

CXCL14,FN1,JAM3,MMP10,MMP11,MMP17,MMP2,

MMP9,MYH11,MYL4,MYL9,PODXL,PPBP,TNFRSF1A

Granulocyte Adhesion and Diapedesis

< 0.001

CCL23,CDH5,CLDN10,CLDN2,CXCL12,CXCL14,JAM3,

MMP10,MMP11,MMP17,MMP2,MMP9,PPBP,SDC2,

SDC3,THY1,TNFRSF1A

GP6 Signaling Pathway

< 0.001

3.77

COL13A1,COL16A1,COL18A1,COL1A1,COL1A2,COL3A1,

COL4A1,COL4A2,COL4A6,COL5A1,COL5A2,COL6A1,

COL6A2,COL6A3,LAMA1,LAMB1,LAMB3,NOX1

Axonal Guidance Signaling

< 0.001

ADAM19,ADAMTS1,ADAMTS13,ADAMTS9,BMP4,BMP6,

CFL2,CXCL12,ECEL1,EFNB1,EPHB2,FZD6,GNB1L,HHIP,

LINGO1,MMP10,MMP11,MMP17,MMP2,MMP9,MYL4,

MYL9,NRP2,NTN3,NTN4,PDGFD,PLCD3,PLXND1,PTCH2,

RASD2,SDC2,SEMA3F,TUBA4A,UNC5B,UNC5C,WNT2B,

WNT4

Inhibition of Matrix Metalloproteases

< 0.001

-1.13

HSPG2,MMP10,MMP11,MMP17,MMP2,MMP9,SDC2,

TFPI2,TIMP2

Apelin Liver Signaling Pathway

0.002

2.45

COL18A1,COL1A1,COL1A2,COL3A1,IRS1,PDGFRB

Intrinsic Prothrombin Activation Pathway

0.014

1.34

COL18A1,COL1A1,COL1A2,COL3A1,PROS1

Inhibition of Angiogenesis by TSP1

0.029

0.00

CD36,HSPG2,MMP9,NOS3,SDC2,THBS1

Leukocyte Extravasation Signaling

0.044

1.90

ACTA2,CDH5,CLDN10,CLDN2,CXCL12,CYBB,JAM3,MMP10,

MMP11,MMP17,MMP2,MMP9,NOX1,THY1,TIMP2