SNP ID
|
SSCb
|
SNP Position (bp)
|
MAFc
|
Traitd
|
Bloode
|
FDR
|
GVar (%)f
|
1-Mb window start SNPg position (bp)
|
Dominance effect ± standard error
|
Additive effecti ± standard error
|
---|
SNP10h: rs319452131
|
1
|
18,792,764
|
0.37
|
MCV
|
Blood 1
|
0.003
|
0.18
|
18,536,535
|
−0.16 ± 0.18
|
0.52 ± 0.14j
|
| | | |
Blood 3
|
0.004
|
0.21
|
18,546,024
|
0.03 ± 0.13
|
0.52 ± 0.10
|
| | | |
Blood 4
|
0.02
|
0.15
|
18,536,535
|
−0.02 ± 0.14
|
0.37 ± 0.11
|
SNP11h: rs1109789977
|
5
|
64,520,638
|
0.31
|
PLT
|
Blood 1
|
0.001
|
0.09
|
63,861,170
|
−3.80 ± 6.83
|
26.78 ± 5.18
|
| | | |
Blood 3
|
0.001
|
0.09
|
63,861,170
|
−9.28 ± 7.44
|
23.92 ± 5.39
|
| | | |
Blood 4
|
0.03
|
0.05
|
63,861,170
|
−10.57 ± 7.40
|
18.33 ± 5.46
|
SNP12h: rs320615395
|
9
|
40,919,049
|
0.45
|
MCH
|
Blood 1
|
0.03
|
0.05
|
39,919,771
|
0.07 ± 0.08
|
0.21 ± 0.07
|
| | | |
Blood 3
|
0.04
|
0.07
|
40,490,005
|
−0.04 ± 0.05
|
0.19 ± 0.05
|
| | | |
Blood 4
|
0.04
|
0.06
|
40,490,005
|
0.03 ± 0.05
|
0.21 ± 0.05
|
SNP13: rs80784550
|
11
|
13,749,336
|
0.12
|
MCHC
|
Δ14
|
0.02
|
0.07
|
13,011,748
|
1.89 ± 2.42
|
2.38 ± 2.33
|
SNP14h: rs323585109
|
12
|
22,234,265
|
0.3
|
MCV
|
Blood 3
|
0.04
|
0.08
|
21,749,390
|
−0.06 ± 0.14
|
−0.40 ± 0.10
|
- aThe most significant SNP without a group of supportive SNPs
- bSus scrofa chromosome
- cMinor allele frequency
- dMCV mean corpuscular volume, PLT platelet concentration, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration
- eBlood 1, Blood 3, and Blood4: CBC measured in blood samples collected at 2-weeks before, and 2- and 6-weeks after a polymicrobial infectious challenge; Δ14: the change of CBC measures from Blood 1 collected at 2-weeks before the challenge to Blood 4 collected at 6-weeks after the challenge
- fThe largest percentage of additive genetic variance explained by the top significant SNP and its adjacent SNPs in a 1 Mb window
- gPositions of the start SNP for the 1 Mb window segment with the largest amount of additive genetic variance
- hSNPs identified and results estimated by multivariate SSGWAS
- iEstimates of additive effects per additional copy of the “B” allele. When the dominance effect was not significant (p > 0.05) the estimate of the additive effect was based on a model without the dominance effect
- jSignificant estimates of additive and dominance effects are highlighted in bold (p < 0.05)