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Table 4 Candidate genes located within 1 Mb on either side of the top significant SNPsa that have been reported by previous studies of pigs, human, mice, and rats to be functionally and biologically related to CBC traits

From: Investigating the genetic architecture of disease resilience in pigs by genome-wide association studies of complete blood count traits collected from a natural disease challenge model

SNPID Traitsb Browsing region Candidate genes and locations
SNP1 Eosinophils SSC4: 92,647,202 bp – 94,647,202 bp ARHGEF2 (94,026,391 bp – 94,082,206 bp)
SNP2 Eosinophils SSC10: 7,186,695 bp – 9,186,695 bp TGFB2 (8,327,779 bp – 8,435,306 bp)
SNP3 Eosinophils SSC12: 35,308,994 bp – 37,308,994 bp MIR21 (36,065,267 bp – 36,065,358 bp)
SNP4 Monocytes SSC2: 119,341,201 bp – 121,341,201 bp COMMD10 (120,238,623 bp – 120,429,913 bp), ATG12 (119,948,443 bp – 119,965,702 bp), CDO1 (119,928,476 bp – 119,940,425 bp), TMED7 (119,794,608 bp – 119,804,406 bp), TICAM2 (119,758,636 bp – 119,760,759 bp)
SNP5 Monocytes SSC9: 104,461,701 bp – 106,461,701 bp NAMPT (106,121,909 bp – 106,161,841 bp)
SNP6 Red blood cells SSC4: 90,591,493 bp – 92,591,493 bp SPTA1 (91,485,067 bp – 91,640,063 bp), MNDA (91,416,410 bp – 91,433,243 bp), ACKR1 (91,221,889 bp – 91,225,651 bp)
SNP7 Red blood cells SSC6: 27,511,423 bp – 29,511,423 bp CBFB (27,684,030 bp – 27,776,751 bp), THAP11 (28,465,458 bp – 28,466,387 bp), PSMB10 (28,544,910 bp – 28,547,609 bp), LCAT (28,550,363 bp – 28,553,512 bp), SLC12A4 (28,554,162 bp – 28,576,458 bp)
SNP8 Red blood cells SSC8: 40,156,538 bp – 42,156,538 bp PDGFRA (40,967,493 bp – 41,021,442 bp), KIT (41,402,334 bp – 41,492,306 bp)
SNP9 Platelets SSC17: 58,739,745 bp – 60,739,745 bp GNAS (59,031,820 bp – 59,053,022 bp), TUBB1 (59,161,420 bp – 59,168,385 bp)
SNP10 Red blood cells SSC1: 17,792,764 bp – 19,792,764 bp STXBP5 (18,345,363 bp – 18,513,252 bp), RAB32 (18,870,875 bp – 19,097,892 bp)
SNP11 Platelets SSC5: 63,520,638 bp – 65,520,638 bp VWF (64,517,593 bp – 64,655,938 bp), CD9 (64,420,177 bp – 64,459,776 bp), GNB3 (63,863,656 bp – 63,870,396 bp), PHB2 (63,751,566 bp – 63,756,480 bp)
SNP12 Red blood cells SSC9: 39,919,049 bp – 41,919,049 bp ZBTB16 (41,639,701 bp – 41,836,742 bp)
SNP13 Red blood cells SSC11: 12,749,336 bp – 14,749,336 bp TRPC4 (13,300,556 bp – 13,517,568 bp), FREM2 (13,959,865 bp – 14,154,246 bp)
SNP14 Red blood cells SSC12: 21,234,265 bp – 23,234,265 bp RARA (22,047,442 bp – 22,085,674 bp), THRA (22,270,062 bp – 22,296,618 bp)
  1. aThe most significant SNP above the genome-wise FDR of 0.05 in each genomic region
  2. bThe category of traits that associated with candidate genes