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Table 4 CNVRs found in common between the AGS and GLGS-UGLI cohorts

From: Genome-wide CNV investigation suggests a role for cadherin, Wnt, and p53 pathways in primary open-angle glaucoma

 

AGS

GLGS-UGLI

AGS + GLGS-UGLI

Genes

Type

P-value

Cases %

Controls %

Type

P-value

Cases %

Controls %

P-value

Adjusted p-value

SDHB

Loss

6.22e-04

14.5

2.48

Gain

4.70e-02

1.71

0.458

3.30e-04

3.71e-04

SCN1A

Gain

3.02e-02

0.763

5.79

Gain

2.06e-14

2.23

13.6

4.66e-14

1.40e-13

Loss

4.91e-02

0.685

0

COL3A1

Gain

1.15e-02

0

4.96

Gain

1.74e-03

0.856

3.51

8.47e-05

1.09e-04

Loss

3.70e-02

6.11

0.826

MFSD8

Loss

5.54e-04

13

1.65

Gain

7.39e-05

1.54

5.8

2.21e-06

3.98e-06

ZDHHC11

Loss

3.70e-02

6.11

0.826

Loss

7.00e-03

5.99

2.75

2.40e-03

2.40e-03

NIPBL

Loss

7.29e-03

6.11

0

Gain

1.75e-10

2.4

11.5

3.17e-11

7.13e-11

Loss

3.70e-02

6.11

0.826

APC

Loss

5.85e-03

13

3.31

Gain

3.03e-05

1.2

5.5

4.40e-06

6.60e-06

HLA-DRB1, HLA-DRB5, HLA-DRB6

Loss

3.68e-02

29

17.4

Gain

2.24e-06

10.4

20.2

1.11e-16

9.99e-16

Loss

8.61e-03

13.7

4.13

Loss

4.56e-12

19.3

6.41

BRCA2

Loss

1.15e-04

37.4

15.7

Gain

9.58e-13

4.79

17.4

3.55e-15

1.60e-14

Loss

9.27e-03

1.88

0.305

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BMC Genomics

ISSN: 1471-2164

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