Table 6 Pathway analysis using the PANTHER classification system in genes reported in the CNVRs identified in both cohorts
PANTHER Pathways | Number of genes | Fold Enrichment | Direction (+/−) | P-value | Genes |
|---|---|---|---|---|---|
Cadherin signalling pathway | 11 | 16.29 | + | 2.23e-08 | PCDHA1, PCDHA2, PCDHA3, PCDHA4, PCDHA5, PCDHA6, PCDHA7, PCDHA8, PCDHA9, PCDHA10, TCF3 |
p53 pathway feedback loops 2 | 4 | 18.96 | + | 1.21e-02 | PRB1, PTEN, ATM, HRAS |
Wnt signalling pathway | 12 | 8.97 | + | 2.01e-06 | APC, PCDHA1, PCDHA2, PCDHA3, PCDHA4, PCDHA5, PCDHA6, PCDHA7, PCDHA8, PCDHA9, PCDHA10, TCF3 |