Fig. 1

Prioritizing gene around CLIC3, PTGDS and C9orf142 in pleiotropic association with CCT in the participants of European ancestry using CAGE eQTL data. Top plot, grey dots represent the -log₁₀(P values) for SNPs from the GWAS of CCT, and rhombuses represent the -log₁₀(P values) for probes from the SMR test with solid rhombuses indicating that the probes pass HEIDI test and hollow rhombuses indicating that the probes do not pass the HEIDI test. Middle plot, eQTL results. Bottom plot, location of genes tagged by the probes. CCT central corneal thickness, GWAS genome-wide association studies, SMR summary data-based Mendelian randomization, HEIDI heterogeneity in dependent instruments, eQTL expression quantitative trait loci