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Fig. 2 | BMC Genomics

Fig. 2

From: Mendelian randomization analysis identified genes pleiotropically associated with central corneal thickness

Fig. 2

Prioritizing gene around RP11-458F8.4 in pleiotropic association with CCT in the participants of European ancestry using GTEx eQTL data. Top plot, grey dots represent the -log10(P values) for SNPs from the GWAS of CCT, and rhombuses represent the -log10(P values) for probes from the SMR test with hollow rhombuses indicating that the probes do not pass the HEIDI test. Middle plot, eQTL results. Bottom plot, location of genes tagged by the probes. CCT central corneal thickness, GWAS genome-wide association studies, SMR summary data-based Mendelian randomization, HEIDI heterogeneity in dependent instruments, eQTL expression quantitative trait loci

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