|
eQTL data
|
Gene ID
|
Gene
|
CHR
|
Top SNP
|
PeQTL
|
PGWAS
|
Beta
|
SE
|
PSMR
|
PHEIDI
|
Q value
|
|---|
|
CAGE
|
ILMN_1796423
|
CLIC3
|
9
|
rs908839
|
8.48 × 10−75
|
6.88 × 10−14
|
6.171
|
0.890
|
4.15 × 10−12
|
2.59 × 10− 1
|
6.79 × 10−8
|
|
ILMN_1664464
|
PTGDS
|
9
|
rs885070
|
7.83 × 10−33
|
3.43 × 10−11
|
8.474
|
1.463
|
6.88 × 10−9
|
9.97 × 10−4
|
4.41 × 10−5
|
|
ILMN_1761138
|
C9orf142
|
9
|
rs4542025
|
1.08 × 10−21
|
4.93 × 10− 13
|
11.896
|
2.063
|
8.09 × 10−9
|
1.02 × 10− 2
|
4.41 × 10− 5
|
|
ILMN_2198408
|
MFF
|
2
|
rs7560053
|
~ 0
|
1.37 × 10−7
|
−1.834
|
0.351
|
1.71 × 10− 7
|
2.36 × 10−3
|
6.99 × 10− 4
|
|
ILMN_1714108
|
TP53INP1
|
8
|
rs896853
|
2.29 × 10−33
|
4.09 × 10− 8
|
−6.119
|
1.226
|
5.96 × 10− 7
|
1.42 × 10−1
|
1.95 × 10−3
|
|
ILMN_1802894
|
VKORC1L1
|
7
|
rs2460421
|
4.93 × 10−46
|
3.57 × 10− 7
|
− 5.016
|
1.046
|
1.64 × 10−6
|
6.08 × 10− 5
|
4.46 × 10−3
|
|
ILMN_1766859
|
MSL2
|
3
|
rs13433683
|
2.00 × 10−44
|
1.17 × 10−6
|
4.751
|
1.035
|
4.40 × 10−6
|
1.97 × 10− 1
|
0.010
|
|
ILMN_1781560
|
ST3GAL6
|
3
|
rs2439225
|
1.80 × 10−58
|
2.04 × 10−6
|
4.043
|
0.887
|
5.23 × 10−6
|
1.83 × 10−2
|
0.011
|
|
ILMN_1716651
|
RUNX2
|
6
|
rs1200428
|
8.94 × 10−170
|
5.21 × 10−6
|
2.142
|
0.476
|
6.92 × 10−6
|
1.87 × 10−1
|
0.013
|
|
ILMN_1680171
|
MFF
|
2
|
rs7572491
|
3.84 × 10−16
|
1.47 × 10−7
|
−9.712
|
2.199
|
1.00 × 10−5
|
3.13 × 10−1
|
0.016
|
|
ILMN_1785635
|
BRD3
|
9
|
rs457420
|
5.98 × 10−47
|
4.23 × 10−6
|
−4.571
|
1.043
|
1.18 × 10−5
|
8.29 × 10−3
|
0.018
|
|
ILMN_2188204
|
ATG12
|
5
|
rs6872406
|
4.42 × 10−61
|
8.61 × 10− 6
|
3.638
|
0.847
|
1.74 × 10−5
|
8.65 × 10−2
|
0.024
|
|
GTEx
|
ENSG00000273142.1
|
RP11-458F8.4
|
7
|
rs4718424
|
3.54 × 10−25
|
2.02 × 10−12
|
6.017
|
1.034
|
5.89 × 10−9
|
3.58 × 10−3
|
5.76 × 10−5
|
|
ENSG00000214402.6
|
LCNL1
|
9
|
rs11145951
|
1.84 × 10−13
|
9.02 × 10− 16
|
10.562
|
1.946
|
5.67 × 10−8
|
4.65 × 10−1
|
2.77 × 10−4
|
|
ENSG00000107317.7
|
PTGDS
|
9
|
rs868102
|
8.79 × 10−20
|
2.18 × 10−10
|
9.142
|
1.756
|
1.92 × 10−7
|
8.55 × 10−2
|
6.24 × 10−4
|
|
ENSG00000226824.2
|
RP4-756H11.3
|
7
|
rs6979488
|
3.99 × 10−30
|
4.92 × 10−8
|
2.943
|
0.598
|
8.66 × 10−7
|
9.24 × 10−5
|
0.002
|
|
ENSG00000170175.6
|
CHRNB1
|
17
|
rs12600861
|
3.47 × 10−17
|
9.03 × 10−7
|
4.382
|
1.033
|
2.20 × 10−5
|
1.89 × 10−1
|
0.037
|
|
ENSG00000164938.9
|
TP53INP1
|
8
|
rs2340586
|
1.17 × 10−10
|
1.95 × 10−8
|
− 19.873
|
4.694
|
2.30 × 10−5
|
6.53 × 10− 1
|
0.037
|
- *The GWAS summarized data were provided by the study of Iglesias et al. and can be downloaded at https://datashare.is.ed.ac.uk/handle/10283/2976. The CAGE and GTEx eQTL data can be downloaded at https://cnsgenomics.com/data/SMR/#eQTLsummarydata
- PeQTL is the P-value of the top associated cis-eQTL in the eQTL analysis, and PGWAS is the P-value for the top associated cis-eQTL in the GWAS analysis. Beta is the estimated effect size in SMR analysis, SE is the corresponding standard error, PSMR is the P-value for SMR analysis and PHEIDI is the P-value for the HEIDI test.
- FDR was calculated at P = 10− 3 threshold
- Bold font means statistical significance after correction for multiple testing using FDR
- CAGE Consortium for the Architecture of Gene Expression, CCT central corneal thickness, CHR chromosome, eQTL expression quantitative trait loci, GTEx Genotype-Tissue Expression, HEIDI heterogeneity in dependent instruments, SNP single-nucleotide polymorphism, SMR summary data-based Mendelian randomization, FDR false discovery rate, GWAS genome-wide association studies
