Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth

BMC Genomics

Table 4 Correlation analysis of VTRNA2-1 methylation levels and risk factors of preterm birth

Variable	Maternal age	Education	Parity	Diagnosis^b	WBC
VTRNA2-1_pos1	0.183	-0.107	-0.019	0.273^*	0.105
VTRNA2-1_pos2	0.169	-0.095	-0.020	0.279^*	0.104
VTRNA2-1_pos3	0.174	-0.147	-0.009	0.293^**	0.094
Hypo vs. Elevated^a	0.179	-0.128	-0.011	0.246^*	0.075

The association between the categorical data for VTRNA2-1 methylation and the categorical data for preterm birth risks were analyzed using Fisher’s exact test. The association between the others and VTRNA2-1 methylation were analyzed using Pearson correlation analysis
VTRNA2-1_pos1, _pos2, and _pos3 were analyzed by pyrosequencing as CpG sites of chromosome 5:135,416,205, chromosome 5:135,416,207, and chromosome 5:135,416,214, respectively
^aIt divided two groups as hypomethylation (< 13 %) and elevated methylation (30–60 %)
^bDiagnosis were analysed by substituting 1 for PTL, a nominal variable, and 2 for pPROM
^*p < 0.05
^**p < 0.01

ISSN: 1471-2164