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Table 4 Correlation analysis of VTRNA2-1 methylation levels and risk factors of preterm birth

From: Elevated methylation of the vault RNA2-1 promoter in maternal blood is associated with preterm birth

Variable Maternal age Education Parity Diagnosisb WBC
VTRNA2-1_pos1 0.183 -0.107 -0.019 0.273* 0.105
VTRNA2-1_pos2 0.169 -0.095 -0.020 0.279* 0.104
VTRNA2-1_pos3 0.174 -0.147 -0.009 0.293** 0.094
Hypo vs. Elevateda 0.179 -0.128 -0.011 0.246* 0.075
  1. The association between the categorical data for VTRNA2-1 methylation and the categorical data for preterm birth risks were analyzed using Fisher’s exact test. The association between the others and VTRNA2-1 methylation were analyzed using Pearson correlation analysis
  2. VTRNA2-1_pos1, _pos2, and _pos3 were analyzed by pyrosequencing as CpG sites of chromosome 5:135,416,205, chromosome 5:135,416,207, and chromosome 5:135,416,214, respectively
  3. aIt divided two groups as hypomethylation (< 13 %) and elevated methylation (30–60 %)
  4. bDiagnosis were analysed by substituting 1 for PTL, a nominal variable, and 2 for pPROM
  5. *p < 0.05
  6. **p < 0.01